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  4. Recombinant Mouse Cysteine and glycine-rich protein 2 (Csrp2)

Recombinant Mouse Cysteine and glycine-rich protein 2 (Csrp2)

  • 中文名称：
    Recombinant Mouse Cysteine and glycine-rich protein 2(Csrp2),Yeast
  • 货号：
    CSB-YP006084MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and glycine-rich protein 2(Csrp2),Yeast
  • 货号：
    CSB-EP006084MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and glycine-rich protein 2(Csrp2),Yeast
  • 货号：
    CSB-EP006084MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and glycine-rich protein 2(Csrp2),Yeast
  • 货号：
    CSB-BP006084MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and glycine-rich protein 2(Csrp2),Yeast
  • 货号：
    CSB-MP006084MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Csrp2
  • Uniprot No.：
  • 别名：
    Csrp2; Dlp1Cysteine and glycine-rich protein 2; Cysteine-rich protein 2; CRP2; Double LIM protein 1; DLP-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-193
  • 氨基酸序列
    MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESAQPHRP TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
  • 基因功能参考文献：
    1. CRP2 localization dynamics, which affect CRP2 function, are regulated by the formation of actin stress fibers in conjunction with smooth muscle cell differentiation. PMID: 21718689
    2. Although CRP2 expression during development is independent of CArG box, its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors. PMID: 20075421
    3. evolutionarily conserved Lin-11, Isl-1, Mac-3 (LIM) domain protein that have been implicated in cell differentiation. PMID: 11748300
    4. Presence of vascular smooth muscle cell-specific element(s) within bp -573 to -550 of CSRP2 5'-flanking sequence. Transcriptional regulation of CSRP2 gene is not dependent on dominant-negative serum response factor. PMID: 12791591
    5. CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity. PMID: 17185421
    6. CRP2 is a new downstream effector of cGMP/cGMP-dependent protein kinase I (cGKI)-mediated spinal nociceptive processing that plays an inhibitory role in the generation of inflammatory pain. PMID: 18256252
    7. Lack of Csrp2 is associated with alterations in cardiomyocyte thickness and hypertrophy in mice. PMID: 18713466

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:13008

    UniGene: Mm.2020