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  4. Recombinant Mouse Cystatin-8 (Cst8)

Recombinant Mouse Cystatin-8 (Cst8)

  • 中文名称：
    Recombinant Mouse Cystatin-8(Cst8),Yeast
  • 货号：
    CSB-YP006096MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystatin-8(Cst8),Yeast
  • 货号：
    CSB-EP006096MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystatin-8(Cst8),Yeast
  • 货号：
    CSB-EP006096MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cystatin-8(Cst8),Yeast
  • 货号：
    CSB-BP006096MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystatin-8(Cst8),Yeast
  • 货号：
    CSB-MP006096MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cst8
  • Uniprot No.：
  • 别名：
    Cst8; CresCystatin-8; Cystatin-related epididymal spermatogenic protein; Cystatin-related epididymal-specific protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-142
  • 氨基酸序列
    V GVDQSKNEVK AQNYFGSINI SNANVKQCVW FAMKEYNKES EDKYVFLVDK ILHAKLQITD RMEYQIDVQI SRSNCKKPLN NTENCIPQKK PELEKKMSCS FLVGALPWNG EFNLLSKECK DV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Performs a specialized role during sperm development and maturation.
  • 基因功能参考文献：
    1. A 14-kDa CRES isoform resides in the outer dense fibers of the sperm tail. PMID: 23269664
    2. data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens PMID: 23185254
    3. CRES may be a regulator of PC4 in sperm-egg interaction and fertilization. PMID: 22827436
    4. loss of CRES has a significant impact on the structure and functions of the testis and epididymis. However, the observed pathologies were prevalent in aged but not in younger adult mice, suggesting that the effects of the loss of CRES are cumulative PMID: 21051588
    5. These results suggest that mice lacking CRES may have altered local levels of cAMP/PKA activity, or that the CRES defect does not directly involve cAMP/PKA but other signaling pathways that regulate protein tyrosine phosphorylation and capacitation. PMID: 20811015
    6. CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing. PMID: 12479114
    7. cystatin-related epididymal spermatogenic protein (CRES) is a competitive inhibitor of prohormone convertase 2 and may regulate proprotein processing within the reproductive and neuroendocrine systems PMID: 12586766
    8. Cres promoter contains the DNA elements necessary for germ cell and pituitary gland-specific expression but lacks critical sequences necessary for expression in the epididymis and ovary. PMID: 15713831
    9. studies suggest that Cres mRNA and protein are low at peak gonadotrope secretory activity, possibly as a means to allow proprotein processing events to occur that are integral to gonadotrope function PMID: 16837735
    10. The Cres gene displays a specific age-dependent expression pattern in mouse testis and epididymis on both the mRNA and protein level. PMID: 17486270

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Cystatin family
  • 组织特异性：
    Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.
  • 数据库链接：

    KEGG: mmu:13012

    STRING: 10090.ENSMUSP00000028931

    UniGene: Mm.20435