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  4. Recombinant Mouse Coiled-coil domain-containing protein 79 (Ccdc79)

Recombinant Mouse Coiled-coil domain-containing protein 79 (Ccdc79)

  • 货号：
    CSB-YP807448MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807448MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807448MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807448MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807448MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Terb1
  • Uniprot No.：
  • 别名：
    Terb1; Ccdc79Telomere repeats-binding bouquet formation protein 1; Coiled-coil domain-containing protein 79
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-768
  • 氨基酸序列
    MESEKPKKTQ EMKTDLKLLL ECLKYHMGNP LSQKEVLITI HSVCKQNSDA GIYFREIGGL MFIINLAKSS EQSLVKEAAL YTLGSIAEEN VYCQQSLCTS ELFQDLTGLL TNDDSNTNLK RMSVYVLLVL VSNNRNGQTL VREVGCIEVL SQMFRTVLSN YELNLSDNSV FQSYLLWSSV CSTLCVCVNN PQNDENQMLC CSLFPCVNEW VMNCMRPEVI RPICSFIGLT LANNTHAQNC FVSSGGLDVL CQVLVQLESD SHNTLSSAKL AVIVTKTMDA CITDNSAAFT VVLSKYHIVS TLLALLLHES LDSREKFSII LAIGHCTEDC EKNQYELLKN NGLPLMIQAL TEFKNEDLSK AATYVLHNCK KITGKLSLSL GQNSFGENEI ELKDISEKET LREHWKAAKE ILCRIKQFEK GGKEEKQQNR SGHYKDNTPS MKVNIQTNLK RLCADSTGGT RAEDKDINQS RELRSYKPSE IMSKACANEN QLTTRKKNTN PVHPFCKEKG QSKIVHETTP SCAQNLDKEK TFDQKDSVSQ SSDQVLKHLP HTVKNRKQVP ETDPFTLCLD IIDREVGIQA TDSCSRMLKY TCSGCIVARK LLNSRNFSKF LHSCAYQCVH HKVIMEAEDK YKNELRKTFI CAKKILLTPC RRRQLCKEST ASEELKIVHQ KPDSKKLPGL EAQALNTSIP EAMERRSPVP GQSGLHKKRR IRKDFTKEEV NYLFHGVKTM GNHWNSILWS FPFQKGRRAV DLAHKYHRLI KGPSCAAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
  • 基因功能参考文献：
    1. T2B domain in TERB1 is essential for telomere and nuclear envelope attachment. PMID: 29141207
    2. loss of telomere structure mediated by the TERB1-TRF1 interaction significantly affects homologous pairing of the telomere-adjacent pseudoautosomal region (PAR) of the X and Y chromosomes in mouse spermatocytes. PMID: 29083416
    3. The coiled-coil-domain containing protein 79 (CCDC79) is a meiosis specific telomere-associated protein in mice. PMID: 24885367
  • 亚细胞定位：
    Chromosome, telomere. Nucleus inner membrane.
  • 蛋白家族：
    TERB1 family
  • 组织特异性：
    Expressed in testis and fetal oocytes.
  • 数据库链接：

    KEGG: mmu:320022

    STRING: 10090.ENSMUSP00000067324

    UniGene: Mm.249775