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  4. Recombinant Mouse Cleavage stimulation factor subunit 2 tau variant (Cstf2t)

Recombinant Mouse Cleavage stimulation factor subunit 2 tau variant (Cstf2t)

  • 货号：
    CSB-YP807472MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807472MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807472MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807472MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807472MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cstf2t
  • Uniprot No.：
  • 别名：
    Cstf2t; Kiaa0689; Cleavage stimulation factor subunit 2 tau variant; CF-1 64 kDa subunit tau variant; Cleavage stimulation factor 64 kDa subunit tau variant; CSTF 64 kDa subunit tau variant; TauCstF-64
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-632
  • 氨基酸序列
    MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL IPGKSQPVSG PGPGGPGPSG PGGPGPGPAP GLCPGPNVML NQQNPPAPQP QHLPRRPVKD IPPLMQTSIQ GGIPAPGPIP AAVPGPGPGS LTPGGAMQPQ VGMPVVGPVP LERGQMQISD PRPPMPRGPM PSGGIPPRGL LGDAPNDPRG GTLLSVTGEV EPRGYMGPPH QGPPMHHGHD NRGPASHDMR GGPLAADPRM LIGEPRGPMI DQRGLPMDGR GGRESRGMET RPMETEVLEP RGMERRMETC AMETRGMDAR GLEMRGPGPS SRGPMTGGIQ GPGPINMGAG GPQGPRQVPN IAGVGNPGGT MQGAGIQGGG MQGAGMQGGG MQGAGMQGGG MQGAGMQAGM QGASMQGGMQ GAGMQGASKQ GGGQPSSFSP GQSQVTPQDQ EKAALIMQVL QLTADQIAML PPEQRQSILI LKEQIQKSTG AS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
  • 基因功能参考文献：
    1. Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice PMID: 27812195
    2. This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice. PMID: 26700942
    3. The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes. PMID: 23110235
    4. primarily supports spermatogenesis, but only incidently supports immune cell function PMID: 21489638
    5. tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs. PMID: 20463354
    6. physiologically increased levels of CstF-64 observed in LPS-stimulated RAW macrophages contribute to the changes in expression and alternative polyadenylation of a number of genes PMID: 16207706
    7. These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level. PMID: 16467265
    8. tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements. PMID: 17029590
    9. Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia. PMID: 18077340
    10. The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs. PMID: 19284619

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in testes, where it is restricted to pachytene spermatocytes and spermatids, and in the brain (at protein level).
  • 数据库链接：

    KEGG: mmu:83410

    STRING: 10090.ENSMUSP00000093831

    UniGene: Mm.22031