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  4. Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog (Cln5)

Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog (Cln5)

  • 中文名称：
    Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog(Cln5),Yeast
  • 货号：
    CSB-YP666270MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog(Cln5),Yeast
  • 货号：
    CSB-EP666270MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog(Cln5),Yeast
  • 货号：
    CSB-EP666270MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog(Cln5),Yeast
  • 货号：
    CSB-BP666270MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog(Cln5),Yeast
  • 货号：
    CSB-MP666270MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cln5
  • Uniprot No.：
  • 别名：
    Cln5Ceroid-lipofuscinosis neuronal protein 5 homolog; Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5 homolog; secreted form]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-341
  • 氨基酸序列
    QRWPVPY KRFSFRPKTD PYCQAKYTFC PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH DAVGFRSTLT GKNYTIEWYE LFQLGNCTFP HLRPDKSAPF WCNQGAACFF EGIDDKHWKE NGTLSVVATI SGNTFNKVAE WVKQDNETGI YYETWTVRAG PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT KIFLYSGEPI YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
  • 基因功能参考文献：
    1. neurogenesis is increased in Cln5-deficient mice, which model the childhood neurodegenerative disorder caused by loss of Cln5. PMID: 28733362
    2. Rssults suggested that CLN2, CLN3 and CLN5 genes may play an important role in early embryonal neurogenesis. PMID: 25303899
    3. The simultaneous loss of both Cln1 and Cln5 genes might enhance the typical pathological phenotypes of these mice by disrupting or downregulating shared or convergent pathogenic pathways. PMID: 23065637
    4. In Cln5-deficient mice, early and significant microglial activation is documented that is already evident at 3 months of age; it increases gradually with age and differs between neurons and glia, with the highest expression in microglia. PMID: 22182690
    5. Study found that CLN5 interacts with several other NCL proteins namely, CLN1/PPT1, CLN2/TPP1, CLN3, CLN6 and CLN8. PMID: 19941651
    6. Mouse Cln5 is a soluble lysosomal glycoprotein expressed throughout embryonic brain, increasing during development; prominent expression is observed in cerebellar Purkinje cells, cerebral neurons, hippocampal pyramidal cells, and hippocampal interneurons. PMID: 15207259
    7. because the role of the functionally uncharacterized Cln5 protein remains unclear these studies may offer clues to the unraveling of its possible function(s) PMID: 18371231
    8. In mouse cerebral cortex, microinjection of VEGF-A disrupted CLN-5 and OCLN and induced loss of barrier function PMID: 19174516
    9. These data provide unexpected evidence for a distinctive sequence of neuron loss in the thalamocortical system of Cln5-/- mice, diametrically opposed to that seen in other forms of NCL. PMID: 19385065

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  • 亚细胞定位：
    [Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5 homolog]: Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    CLN5 family
  • 组织特异性：
    Heart, kidney, liver, spleen, muscle and rectum (at protein level).
  • 数据库链接：

    KEGG: mmu:211286

    STRING: 10090.ENSMUSP00000022721

    UniGene: Mm.295289