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  4. Recombinant Mouse Centrosomal protein of 57 kDa (Cep57)

Recombinant Mouse Centrosomal protein of 57 kDa (Cep57)

  • 货号：
    CSB-YP807006MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807006MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807006MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807006MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807006MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cep57
  • Uniprot No.：
  • 别名：
    Cep57; Kiaa0092; Tsp57; Centrosomal protein of 57 kDa; Cep57; Testis-specific protein 57; Translokin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-500
  • 氨基酸序列
    MAAASVSAAS DSQFSSVLAE PSRSNGNMVR HSSSPYVLYP PDKPFLNSDL RRSPNKPTFA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE TIEYKKVLDE QIQERENSKN EESKHNQELA SQLVAAENKC NLLEKQLEYM RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT AMQALAEKKM QELESKLREE EQERKRMQAR AAELQSGLEA NRLIFEDKTT SCVSTSTRKI KKKKSKPPEK KGSRTYFGAQ PHYRLCLGDM PFVAGTSTSP SHAVVANVQH VLHLMKHHSK ALCNDRVVNS VPLAKQACSR VSKSKKSVVP PSSSVNEELS DVLQTLQDEF GQMSFDHQQL TKLIQESPTV ELKDNLECEL EALVGRMEAK ANQITKVRKY QAQLEKQNID KQKKELKANK KTLDEEGNSS GRSSGVPRTA SKKDLAKQRP GEKSRKNLQL LKDMQTIQNS LQSSNLCWDY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.
  • 基因功能参考文献：
    1. Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
    2. Data suggest that translokin acts as a key negative regulator in the pathway that drives nuclear import of cyclin D1, thus contributing to prevent pRB inactivation and to maintain cellular quiescence. PMID: 21306487
    3. report the identification of four Translokin partners: sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B PMID: 19804566
    4. Tsp57 protein plays a role in the postmeiotic phase of germ cell differentiation PMID: 12954732
    5. Data suggest that Cep57 serves as a link with its N-terminus anchored to the centriole or centromatrix and its C-terminus to microtubules. PMID: 18294141

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Translokin family
  • 组织特异性：
    Ubiquitous (at protein level). Expressed in testis, predominantly in round spermatids. Low expression is detected in other tissues.
  • 数据库链接：

    KEGG: mmu:74360

    STRING: 10090.ENSMUSP00000034398

    UniGene: Mm.157212