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  4. Recombinant Mouse Cellular retinoic acid-binding protein 1 (Crabp1)

Recombinant Mouse Cellular retinoic acid-binding protein 1 (Crabp1)

  • 中文名称：
    Recombinant Mouse Cellular retinoic acid-binding protein 1(Crabp1),Yeast
  • 货号：
    CSB-YP005935MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular retinoic acid-binding protein 1(Crabp1),Yeast
  • 货号：
    CSB-EP005935MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular retinoic acid-binding protein 1(Crabp1),Yeast
  • 货号：
    CSB-EP005935MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular retinoic acid-binding protein 1(Crabp1),Yeast
  • 货号：
    CSB-BP005935MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular retinoic acid-binding protein 1(Crabp1),Yeast
  • 货号：
    CSB-MP005935MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crabp1
  • Uniprot No.：
  • 别名：
    Crabp1; Cellular retinoic acid-binding protein 1; Cellular retinoic acid-binding protein I; CRABP-I
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-137
  • 氨基酸序列
    PNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLPTWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
  • 基因功能参考文献：
    1. The physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory. PMID: 28911165
    2. This study reveals a physiological relevance of the non-genomic action of atRA, mediated by Crabp1, in modulating cell cycle progression and apoptosis induction PMID: 26935534
    3. Only a small fraction of CRABP1 populates this functionally important but vulnerable conformation of CRABP1, enabling efficient ligand binding. PMID: 24236614
    4. CRABPI binds to all-trans retinoic acid in the cytoplasm, resulting in rapid ERK1/2 activation that is independent of membrane signal and nuclear RA receptors. PMID: 22982089
    5. These data suggest that CRABPI functions to regulate the intracellular concentrations of retinoic acid and to maintain high levels of oxidized retinoic acid metabolites such as 4-oxoretinoic acid within cells. PMID: 12623064
    6. The expression of CRABP I in the embryonic cerebellum coincides with earliest cerebellar differentiation; its involvement in a complex network of regulatory genes expressed in the mes/methencephalon is discussed in this review. PMID: 15072263
    7. This study presents the first evidence that over-expressed receptor interacting protein 140 acts as a thyroid hormone (T3)-dependent negative co-regulator for T3 induction of the endogenous cellular retinoic acid binding I protein gene in P19 cells. PMID: 15130509
    8. proline isomerization may not be responsible for the slowest folding phase of CRABP I so the loss of a slow refolding phase upon mutation may not be diagnostic for proline isomerization effects on protein folding PMID: 15152096
    9. Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol. PMID: 18006143

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    KEGG: mmu:12903

    STRING: 10090.ENSMUSP00000034830

    UniGene: Mm.34797