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  4. Recombinant Mouse Cartilage matrix protein (Matn1)

Recombinant Mouse Cartilage matrix protein (Matn1)

  • 中文名称：
    小鼠Matn1重组蛋白
  • 货号：
    CSB-YP013520MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Matn1重组蛋白
  • 货号：
    CSB-EP013520MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Matn1重组蛋白
  • 货号：
    CSB-EP013520MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Matn1重组蛋白
  • 货号：
    CSB-BP013520MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Matn1重组蛋白
  • 货号：
    CSB-MP013520MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Matn1
  • Uniprot No.：
  • 别名：
    Matn1; Cmp; CrtmCartilage matrix protein; Matrilin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-500
  • 氨基酸序列
    L VPQPRGHLCR TRPTDLVFVV DSSRSVRPVE FEKVKVFLSQ VIESLDVGPN ATRVGLVNYA STVKPEFPLR AHGSKASLLQ AVRRIQPLST GTMTGLALQF AITKALSDAE GGRARSPDIS KVVIVVTDGR PQDSVRDVSE RARASGIELF AIGVGRVDKA TLRQIASEPQ DEHVDYVESY NVIEKLAKKF QEAFCVVSDL CATGDHDCEQ LCVSSPGSYT CACHEGFTLN SDGKTCNVCR GGGSGSATDL VFLIDGSKSV RPENFELVKK FINQIVDTLD VSDRLAQVGL VQYSSSIRQE FPLGRFHTKK DIKAAVRNMS YMEKGTMTGA ALKYLIDNSF TVSSGARPGA QKVGIVFTDG RSQDYINDAA RKAKDLGFKM FAVGVGNAVE EELREIASEP VADHYFYTAD FKTINQIGKK LQKQICVEED PCACESILKF EAKVEGLLQA LTRKLEAVSG RLAVLENRII
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
  • 基因功能参考文献：
    1. Results provide evidence that Matn1 plays a protective role in cartilage degeneration under altered mechanical environment. PMID: 27270603
    2. Matrilin-1 is an inhibitor of neovascularization PMID: 24692560
    3. Secretion of matrilin 3 V194D mutant protein is not dependent on hetero-oligomerization with matrilin 1. PMID: 22083516
    4. Expression of matrilin-1 during maturation of mouse skeletal tissues PMID: 12009334
    5. The chondrocytes of the presumptive articular surface therefore appear to arise directly from a subpopulation of early chondrocytes that do not activate matrilin-1 expression rather than by redifferentiation from the flattened cells of the interzone. PMID: 17313942
    6. Matrilin-1 and matrilin-3 modulate collagen fibrillogenesis in cartilage and show that biochemical compensation might exist between matrilins, evidenced by Matn3 deficiency. PMID: 17502381
    7. Data show that the cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita. PMID: 17525268
    8. Transgenic mice expressing mutant (D469Delta) cartilage oligomeric matrix protein showed a slight gender specific growth retardation and both, tibial growth plate and sternum abnormalities. PMID: 17889519

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 数据库链接：

    KEGG: mmu:17180

    STRING: 10090.ENSMUSP00000099636

    UniGene: Mm.271796