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  4. Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2 (Ceacam2), partial

Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2 (Ceacam2), partial

  • 中文名称：
    Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2(Ceacam2),partial,Yeast
  • 货号：
    CSB-YP846085MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2(Ceacam2),partial,Yeast
  • 货号：
    CSB-EP846085MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2(Ceacam2),partial,Yeast
  • 货号：
    CSB-EP846085MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2(Ceacam2),partial,Yeast
  • 货号：
    CSB-BP846085MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 2(Ceacam2),partial,Yeast
  • 货号：
    CSB-MP846085MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ceacam2
  • Uniprot No.：
  • 别名：
    Ceacam2; Bgp2; Carcinoembryonic antigen-related cell adhesion molecule 2; CEA-related cell adhesion molecule 2; Biliary glycoprotein 2; BGP-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.; Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium.
  • 基因功能参考文献：
    1. disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function. PMID: 27161904
    2. CEACAM2 regulates insulin secretion, at least in part, by a GLP-1-mediated mechanism, independent of confounding metabolic factors. PMID: 26586918
    3. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling PMID: 25085348
    4. Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis PMID: 24948196
    5. CEACAM2-L might be a novel adhesion molecule contributing to cell-to-cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium PMID: 23070997
    6. Data suggest that CEACAM2 has a role in regulation of metabolic rate and insulin sensitivity/resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, and energy expenditure in skeletal muscle. PMID: 22159884

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 组织特异性：
    Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain i
  • 数据库链接：

    KEGG: mmu:26367

    STRING: 10090.ENSMUSP00000048118

    UniGene: Mm.439731