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  4. Recombinant Mouse CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (St3gal4), partial

Recombinant Mouse CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (St3gal4), partial

  • 中文名称：
    小鼠St3gal4重组蛋白
  • 货号：
    CSB-YP852802MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠St3gal4重组蛋白
  • 货号：
    CSB-EP852802MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠St3gal4重组蛋白
  • 货号：
    CSB-EP852802MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠St3gal4重组蛋白
  • 货号：
    CSB-BP852802MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠St3gal4重组蛋白
  • 货号：
    CSB-MP852802MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    St3gal4
  • Uniprot No.：
  • 别名：
    St3gal4; Siat4c; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Alpha 2,3-ST 4; Beta-galactoside alpha-2,3-sialyltransferase 4; EC 2.4.99.2; EC 2.4.99.6; Alpha 2,3-sialyltransferase IV; Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; ST3Gal IV; ST3GalIV; Sialyltransferase 4C; SIAT4-C
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin.
  • 基因功能参考文献：
    1. The results of this study indicated that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits. PMID: 25066807
    2. St3Gal4-deficient myeloid cells had less binding of Ccl5 and impaired Ccl5-triggered integrin activation. St3Gal4 deficiency reduced the size, stage, and inflammatory cell content of atherosclerotic lesions in Apoe(-/-) mice on high-fat diet. PMID: 24425712
    3. St3gal4, potentially involved in antithrombin sialylation, was 85% lower in neonates in comparison with adults PMID: 23678987
    4. Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction. PMID: 23471032
    5. Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands. PMID: 22700726
    6. operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands PMID: 12097641
    7. was found to play a role in regulating synthesis of selectin ligands and in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells PMID: 12393657
    8. Regulates P-selectin ligand protein, the molecule responsible for L-selectin-mediated leukocyte interactions in inflammation. PMID: 17111351
    9. Sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo. PMID: 18519646

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Broadly expressed among tissues with highest levels in the small intestine and colon.
  • 数据库链接：

    KEGG: mmu:20443

    STRING: 10090.ENSMUSP00000034537

    UniGene: Mm.275973