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  4. Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2 (Cisd2), partial

Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2 (Cisd2), partial

  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2(Cisd2),partial,Yeast
  • 货号：
    CSB-YP887420MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2(Cisd2),partial,Yeast
  • 货号：
    CSB-EP887420MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2(Cisd2),partial,Yeast
  • 货号：
    CSB-EP887420MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2(Cisd2),partial,Yeast
  • 货号：
    CSB-BP887420MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 2(Cisd2),partial,Yeast
  • 货号：
    CSB-MP887420MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cisd2
  • Uniprot No.：
  • 别名：
    Cisd2; Cdgsh2; Noxp70; Zcd2CDGSH iron-sulfur domain-containing protein 2; MitoNEET-related 1 protein; Miner1; Nervous system overexpressed protein 70
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
  • 基因功能参考文献：
    1. CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis PMID: 29166610
    2. These results suggest that the thermosensitive FA-loaded hydrogel could rescue Cisd2(-/-) CM from oxidative stress-induced damage and may have potential applications in the future treatment of CVD. PMID: 27392289
    3. NAF-1, a BCL-2-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle PMID: 22343142
    4. Cisd2 deficiency impairs the activation of Wnt/beta-catenin signaling PMID: 26230298
    5. Results suggest that that Cisd2 plays an important role in intracellular Ca21 homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis in mice. PMID: 24833725
    6. Miner1 is a redox protein that resides in the ER and that regulates the UPR and mitochondrial function. PMID: 23703906
    7. CISD2 has a role in lifespan control and disease [review] PMID: 20649540
    8. Cisd2 deficiency in mice causes mitochondrial breakdown and dysfunction accompanied by autophagic cell death, and these precede nerve and muscle degeneration; together, they lead to a panel of phenotypic features suggestive of premature aging PMID: 19451219

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells.
  • 蛋白家族：
    CISD protein family, CISD2 subfamily
  • 组织特异性：
    Brain.
  • 数据库链接：

    KEGG: mmu:67006

    STRING: 10090.ENSMUSP00000029815

    UniGene: Mm.269993