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  4. Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1 (Cisd1), partial

Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1 (Cisd1), partial

  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1(Cisd1),partial,Yeast
  • 货号：
    CSB-YP856308MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1(Cisd1),partial,Yeast
  • 货号：
    CSB-EP856308MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1(Cisd1),partial,Yeast
  • 货号：
    CSB-EP856308MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1(Cisd1),partial,Yeast
  • 货号：
    CSB-BP856308MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CDGSH iron-sulfur domain-containing protein 1(Cisd1),partial,Yeast
  • 货号：
    CSB-MP856308MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cisd1
  • Uniprot No.：
  • 别名：
    Cisd1; D10Ertd214e; Zcd1CDGSH iron-sulfur domain-containing protein 1; MitoNEET
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions.
  • 基因功能参考文献：
    1. mNEET plays a specific role in the formation of intermitochondrial junctions and thus participates in the adaptation of cells to physiological changes and to the control of mitochondrial homeostasis. PMID: 28716905
    2. Together, these data suggest that mitoNEET KO mice exhibit many of the characteristics of early neurodegeneration in PD and may provide a novel drug discovery platform to evaluate compounds for enhancing mitochondrial function in neurodegenerative disorders. PMID: 28880525
    3. mitoNEET protects intact cardiac cells from oxidative stress induced apoptosis during hypoxia and reoxygenation. PMID: 27243905
    4. The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice. PMID: 27573244
    5. the mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic environment. PMID: 24865177
    6. The MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. PMID: 24295216
    7. study found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue PMID: 22961109
    8. mitoNEET is located in mitochondrial fraction of adipocytes. PMID: 14570702
    9. mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates PMID: 17376863

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    CISD protein family
  • 组织特异性：
    Liver, adipose, skeletal muscle and heart (at protein level). Widely expressed. Expressed at the highest levels in the heart.
  • 数据库链接：

    KEGG: mmu:52637

    STRING: 10090.ENSMUSP00000043559

    UniGene: Mm.254114