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  4. Recombinant Mouse CD180 antigen (Cd180), partial

Recombinant Mouse CD180 antigen (Cd180), partial

  • 中文名称：
    Recombinant Mouse CD180 antigen(Cd180),partial,Yeast
  • 货号：
    CSB-YP714013MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CD180 antigen(Cd180),partial,Yeast
  • 货号：
    CSB-EP714013MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CD180 antigen(Cd180),partial,Yeast
  • 货号：
    CSB-EP714013MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CD180 antigen(Cd180),partial,Yeast
  • 货号：
    CSB-BP714013MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CD180 antigen(Cd180),partial,Yeast
  • 货号：
    CSB-MP714013MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd180; Ly78; Rp105; CD180 antigen; Lymphocyte antigen 78; Ly-78; Radioprotective 105 kDa protein; CD antigen CD180
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
  • 基因功能参考文献：
    1. Silencing Cd180 results in increased phagocytosis while tempering the production of the proinflammatory cytokine TNF during Borrelia burgdorferi infection. PMID: 29511161
    2. the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. PMID: 26277892
    3. Data show that RP105 knockout (-/-) smooth muscle cells and mast cells secreted higher levels of chemokine (C-C motif) ligand 2 protein (CCL2). PMID: 27053419
    4. These data unveil a novel innate immune signaling axis that orchestrates key cytokine responses of macrophages and provide molecular insight into the functions of RP105 as an innate immune receptor for mycobacteria. PMID: 26371254
    5. RP105 regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PMID: 24945347
    6. RP105 deficiency results in reduced early atherosclerotic plaque development with a marked decrease in lesional macrophage content, which may be due to disturbed migration of RP105 deficient monocytes resulting from CCR2 downregulation PMID: 25484103
    7. Deficiency of the endogenous TLR4 inhibitor, RP105, leads to pronounced cardiac dilation after myocardial infarction. PMID: 25156852
    8. Data indicate that RP105 and TLR4 are both expressed by vascular smooth muscle cells (VSMC). PMID: 23844130
    9. RP105 deficiency on circulating cells results in an intriguing unexpected TLR-associated mechanisms that decrease atherosclerotic lesion formation with alterations on proinflammatory B2 B cells. PMID: 24115036
    10. The function of TLR2 and TLR4 in response to TLR ligands could be associated with each other by RP105. PMID: 23483427
    11. Data show that both RP105/MD-1 and TLR4/MD-2 are expressed in marginal zone (MZ) B cells. PMID: 22354914
    12. The RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders. PMID: 22396206
    13. Modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of RP105. PMID: 22291190
    14. Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. PMID: 21959264
    15. CD180 stimulation induces intrinsic B cell proliferation and differentiation PMID: 21918197
    16. RP105 regulated TLR4 signaling in dendritic cells PMID: 15852007
    17. A signal via RP105 is uniquely important for regulating Toll-like receptor-dependent antibody production to microbial membranes. PMID: 15905547
    18. RP105 regulates the antigen-presenting cell function and Treg development, which induced the attenuation of the cell-mediated immune responses and, as a result, suppressed the development of collagen-induced arthritis . PMID: 18847495
    19. The data identify RP105 as an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins. PMID: 19154986

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Toll-like receptor family
  • 组织特异性：
    B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.
  • 数据库链接：

    KEGG: mmu:17079

    STRING: 10090.ENSMUSP00000022124

    UniGene: Mm.373974