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  4. Recombinant Mouse C-type lectin domain family 5 member A (Clec5a), partial

Recombinant Mouse C-type lectin domain family 5 member A (Clec5a), partial

  • 中文名称：
    Recombinant Mouse C-type lectin domain family 5 member A(Clec5a),partial,Yeast
  • 货号：
    CSB-YP879485MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 5 member A(Clec5a),partial,Yeast
  • 货号：
    CSB-EP879485MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 5 member A(Clec5a),partial,Yeast
  • 货号：
    CSB-EP879485MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 5 member A(Clec5a),partial,Yeast
  • 货号：
    CSB-BP879485MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 5 member A(Clec5a),partial,Yeast
  • 货号：
    CSB-MP879485MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clec5a
  • Uniprot No.：
  • 别名：
    Clec5a; Clecsf5; Mdl1C-type lectin domain family 5 member A; C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1; MDL-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.
  • 基因功能参考文献：
    1. MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. PMID: 29126450
    2. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis PMID: 27033255
    3. Data show that C-type lectin member 5A (CLEC5A) is needed for optimal reactive oxygen species (ROS) production, neutrophil extracellular traps (NETs) formation and other immune responses to Listeria monocytogenes in mice. PMID: 28824166
    4. The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. PMID: 27795434
    5. cigarette smoke-induced macrophage responsiveness is mediated by CLEC5A, and CLEC5A is required for the development of inflammation, proinflammatory cytokine expression, and airspace enlargement. PMID: 26927798
    6. Japanese encephalitis virus (JEV) directly interacts with CLEC5A and induces DAP12 phosphorylation in macrophages. PMID: 22536153
    7. triggering of MDL-1 on immature myeloid cells and production of NO and TNF-alpha may play a critical role in the pathogenesis of shock PMID: 22005300
    8. This is the first report that shows the involvement of monocyte and macrophage receptor CLEC5A in severe inflammatory response in Japanese encephalitis virus (JEV) infection of brain. PMID: 20637688
    9. Activation of MDL-1 leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joint and promotes bone erosion. PMID: 20212065
    10. MDL-1 plays an important role in immune defense as a result of an innate immunity, which involves neutrophils and macrophages PMID: 19074552
    11. binding of Dengue virus to macrophages expressing Clec5 initiates cytokine storm pathology PMID: 19120482

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  • 相关疾病：
    Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokines secretion.
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Strong expression in bone marrow cells and thioglycollate-induced neutrophils (at protein level). Expressed on granulocytes and monocytes from bone marrow and peripheral blood. Expressed in macrophage cell line J-774, but not in T-cell lines, B-cell lines
  • 数据库链接：

    KEGG: mmu:23845

    STRING: 10090.ENSMUSP00000121848

    UniGene: Mm.103765