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  4. Recombinant Mouse C-type lectin domain family 1 member B (Clec1b), partial

Recombinant Mouse C-type lectin domain family 1 member B (Clec1b), partial

  • 中文名称：
    Recombinant Mouse C-type lectin domain family 1 member B(Clec1b),partial,Yeast
  • 货号：
    CSB-YP881344MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 1 member B(Clec1b),partial,Yeast
  • 货号：
    CSB-EP881344MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 1 member B(Clec1b),partial,Yeast
  • 货号：
    CSB-EP881344MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 1 member B(Clec1b),partial,Yeast
  • 货号：
    CSB-BP881344MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 1 member B(Clec1b),partial,Yeast
  • 货号：
    CSB-MP881344MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clec1b
  • Uniprot No.：
  • 别名：
    Clec1b; Clec2C-type lectin domain family 1 member B; C-type lectin-like receptor 2; CLEC-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.
  • 基因功能参考文献：
    1. Platelet-specific deletion of CLEC-2 but not GPVI leads to enhanced systemic inflammation and accelerated organ injury in two mouse models of sepsis. Results suggest podoplanin-CLEC-2 as a novel anti-inflammatory axis regulating immune cell recruitment and activation in sepsis. PMID: 29269852
    2. CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk. PMID: 28296036
    3. CLEC-2 was involved in hepatic regeneration after liver resection and was attributed to the interaction between platelets and sinusoidal endothelial cells. PMID: 28294559
    4. CLEC-2 deficiency may inhibit thrombus formation in tumor vessels and increase the density of functional vessels, thus improving oxygen and nutrient supply to tumors, indirectly promoting tumor proliferation PMID: 28028907
    5. these data suggest that the platelet CLEC-2-podoplanin signaling axis regulates the severity of lung inflammation in mice and is a possible novel target for therapeutic intervention in patients at risk of developing ARDS. PMID: 28839100
    6. a hemITAM signaling-independent role for CLEC-2 in hemostasis and thrombosis PMID: 28835437
    7. a novel mechanism of Deep vein thrombosis, whereby CLEC-2 and upregulation of podoplanin expression in the venous wall trigger thrombus formation PMID: 28104688
    8. A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM. PMID: 26796360
    9. A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis PMID: 26151067
    10. Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks). PMID: 26552707
    11. Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36/GPVI (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2). PMID: 25849538
    12. Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels. PMID: 25908104
    13. CLEC-2 signaling promotes adhesion to Podoplanin and regulation of Podoplanin signaling, thereby contributing to lymphatic vasculature development. PMID: 25368330
    14. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor CLEC-2, PDPN endowed FRCs with contractile function and exerted tension within the reticulum. PMID: 25347465
    15. The results demonstrated that CLEC-2-dependent platelet activation is insensitive to cGMP-elevation and only partially sensitive to cAMP-elevation. PMID: 24460629
    16. These data suggest that the function of Pdpn in lymphangiogenesis does not depend on threonine 34 in the CLEC-2 binding domain and that PdpnT34A-Fc might be an improved inhibitor of lymphangiogenesis with fewer toxic side effects. PMID: 24907275
    17. Clec-2 is necessary for lymphatic cell proliferation and lymph node anlage persistence after birth. PMID: 24532804
    18. local sphingosine-1-phosphate release after PDPN-CLEC-2-mediated platelet activation is critical for high endothelial venules integrity during immune responses PMID: 23995678
    19. demonstrate that isolated targeting of either GPVI or CLEC-2 in vivo does not affect expression or function of the respective other receptor PMID: 23448972
    20. activation of CLEC-2 by PDPN rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces. PMID: 22884313
    21. platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 upon activation by CLEC-2/podoplanin in PMID: 22556408
    22. CLEC-2 is not required for platelet aggregation at arteriolar shear PMID: 20695981
    23. CLEC-2 is involved in thrombus stabilization in vitro and in vivo, possibly through homophilic interactions without apparent increase in bleeding tendency PMID: 20525685
    24. A nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development. PMID: 20363774
    25. CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis PMID: 17616532
    26. Two novel splicing variants of mCLEC-2 derived from omission of exon 2 and 2/4, respectively, were indentified in mouse. PMID: 18361921
    27. Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. PMID: 18826392
    28. CLEC-2 functions as an activation receptor on neutrophils. PMID: 19299712
    29. an essential function of CLEC-2 in hemostasis and thrombosis. PMID: 19641185

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Hematopoietic cells, megakaryocytes and platelets.
  • 数据库链接：

    KEGG: mmu:56760

    STRING: 10090.ENSMUSP00000032262

    UniGene: Mm.30700