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  4. Recombinant Mouse Bone morphogenetic protein 3B (Gdf10)

Recombinant Mouse Bone morphogenetic protein 3B (Gdf10)

  • 中文名称：
    小鼠Gdf10重组蛋白
  • 货号：
    CSB-YP009343MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gdf10重组蛋白
  • 货号：
    CSB-EP009343MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gdf10重组蛋白
  • 货号：
    CSB-EP009343MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gdf10重组蛋白
  • 货号：
    CSB-BP009343MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gdf10重组蛋白
  • 货号：
    CSB-MP009343MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gdf10
  • Uniprot No.：
  • 别名：
    Gdf10; Bmp3b; Growth/differentiation factor 10; GDF-10; Bone morphogenetic protein 3B; BMP-3B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    367-476
  • 氨基酸序列
    QWDE PRVCSRRYLK VDFADIGWNE WIISPKSFDA YYCAGACEFP MPKIVRPSNH ATIQSIVRAV GIVPGIPEPC CVPDKMNSLG VLFLDENRNA VLKVYPNMSV ETCACR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
  • 基因功能参考文献：
    1. Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh as early as E18.5, suggesting a regulation of glial development by Shh PMID: 24963847
    2. data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex. PMID: 21712809
    3. Sca-1 attenuated GDF10-dependent TGF-beta signaling by disrupting the heterodimerization of TbetaRI and TbetaRII receptors. PMID: 21518866
    4. Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice. PMID: 14687547
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Highly expressed in epididymal adipose tissue, brain, bone and aorta and to a lesser extent in liver and spleen. Expressed at higher levels in preadipocytes than in mature adipocytes. Strongly expressed in glial cells of the cerebellum.
  • 数据库链接：

    KEGG: mmu:14560

    STRING: 10090.ENSMUSP00000128621

    UniGene: Mm.432071