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  4. Recombinant Mouse Beta-galactoside alpha-2,6-sialyltransferase 1 (St6gal1), partial

Recombinant Mouse Beta-galactoside alpha-2,6-sialyltransferase 1 (St6gal1), partial

  • 中文名称：
    小鼠St6gal1重组蛋白
  • 货号：
    CSB-YP717563MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠St6gal1重组蛋白
  • 货号：
    CSB-EP717563MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠St6gal1重组蛋白
  • 货号：
    CSB-EP717563MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠St6gal1重组蛋白
  • 货号：
    CSB-BP717563MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠St6gal1重组蛋白
  • 货号：
    CSB-MP717563MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    St6gal1
  • Uniprot No.：
  • 别名：
    St6gal1; Siat1; Beta-galactoside alpha-2,6-sialyltransferase 1; Alpha 2,6-ST 1; EC 2.4.99.1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
  • 基因功能参考文献：
    1. Suggest a crucial role for ST6Gal1 in elevating the invasiveness of pancreatic ductal adenocarcinoma cells in a fructose-responsive manner. PMID: 28032597
    2. The data confirm that circulatory ST6Gal-1 is a negative systemic regulator of granulopoiesis PMID: 28550122
    3. Data, including data from studies using knockout mice, suggest that extracellular St6gal1 supports extrinsic sialylation, however, other sialyltransferases appear to be present in systemic circulation. Platelet activation [as demonstrated with the FeCl(3) model of mesenteric artery thrombosis] is minimally sufficient to elicit extrinsic sialylation. PMID: 28717006
    4. B-cell-specific ablation of ST6Gal1 in mice revealed that IgG sialylation can occur in the extracellular environment of the bloodstream independently of the B-cell secretory pathway. We also discovered that secreted ST6Gal1 is produced by cells lining central veins in the liver and that IgG sialylation is powered by serum-localized nucleotide sugar donor CMP-sialic acid that is at least partially derived from degranulat PMID: 27303031
    5. findings suggest that ST6GAL1 has an inhibitory role in adipogenesis through integrin-beta1 activation, providing new insights into the roles and regulation mechanisms of glycans in adipocytes during obesity PMID: 28031460
    6. this study proposes that remotely produced, rather than the endogenously expressed, ST6Gal-1 is the principal modifier of HSPC glycans for alpha2,6-sialic acids. In so doing, liver-produced ST6Gal-1 may be a potent systemic regulator of hematopoiesis. PMID: 24425878
    7. Altered levels of ST6GAL1 are responsible for changed invasive properties of Hca-F and Hca-P cells both in vitro and in vivo. PMID: 23840320
    8. Caveolin-1 up-regulates integrin alpha2,6-sialylation to promote integrin alpa5beta1-dependent hepatocarcinoma cell adhesion. PMID: 23416306
    9. these results demonstrate for the first time that caveolin-1 can up-regulate ST6Gal-I expression and further contribute to promoting mouse hepatocarcinoma cell adhesion to fibronectin by activating FAK-mediated adhesion signaling. PMID: 23022190
    10. Data indicate that the P1 promoter of the ST6Gal-1 gene is critical for Fc sialylation. PMID: 22427662
    11. the loci of disulphide linkages in ST6Gal-I differ from those in ST3Gal I, suggesting that the linkage specificity of sialyltransferase may results from significant structural differences, including the loci of disulphide linkages (ST6Gal-I) PMID: 22039275
    12. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor. PMID: 21930713
    13. Data show that the sialyltransferase enzymes St6gal1 and St3gal4 are responsible for the production of sialyllactose in mouse milk. PMID: 21098096
    14. circulatory ST6Gal-1, mostly of hepatic origin, limits myelopoiesis by a mechanism independent of hepatic sialylation of serum glycoproteins PMID: 20529847
    15. The data implicate ST6Gal-1 as a participant in regulating not only Th1 but also Th2 responses, and ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production. PMID: 20007243
    16. tissue-specific alterations in sialylation and sialic acid 9-O-acetylation in knockout mice PMID: 12068010
    17. ST6Gal I sialyltransferase has a role in regulating galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death PMID: 12499376
    18. Siat1deltaP1 animals can't raise liver Siat1 mRNA as inflammatory response; serum glycoprotein and B cells have normal sialylation; on exposure to S typhimurium, accumulation of neutrophils and greater burden in liver and spleen was observed. PMID: 12672700
    19. Ras oncogene induces ST6gal1 via a RalGEF-mediated signal to its housekeeping promoter. PMID: 15355339
    20. BACE1 cleaves ST6Gal I in vivo and controls the secretion of the E41 form of the ST6Gal I protein PMID: 15364953
    21. Protein glycosylation by ST6Gal-I restricts access of antigen receptors and Shp-1 to CD22 and operates by a CD22-dependent mechanism. PMID: 16782884
    22. role for ST6Gal-1, possibly from extramedullary sources (eg, produced in liver) in regulating inflammation, circulating neutrophil homeostasis, and replenishing granulocyte numbers. PMID: 16849643
    23. soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins PMID: 17897958
    24. A role for ST6Gal-I as a mediator of tumor progression. PMID: 18199532
    25. Reduced thymic cellularity in the ST6Gal I-deficient mice starting in the early thymocyte compartments. PMID: 18535087
    26. ST6Gal I(-/-) mice show comparable numbers of IgG influenza-specific memory B cells and long-lived plasma cells, with similarly high antiviral IgG titers, with the exception of IgG2c PMID: 19342648

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 数据库链接：

    KEGG: mmu:20440

    STRING: 10090.ENSMUSP00000023601

    UniGene: Mm.149029