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Recombinant Mouse Beta-defensin 3 (Defb3)

  • 中文名称：
    Recombinant Mouse Beta-defensin 3(Defb3),Yeast
  • 货号：
    CSB-YP892972MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-defensin 3(Defb3),Yeast
  • 货号：
    CSB-EP892972MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-defensin 3(Defb3),Yeast
  • 货号：
    CSB-EP892972MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-defensin 3(Defb3),Yeast
  • 货号：
    CSB-BP892972MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-defensin 3(Defb3),Yeast
  • 货号：
    CSB-MP892972MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Defb3
  • Uniprot No.：
  • 别名：
    Defb3; Bd3Beta-defensin 3; BD-3; mBD-3; Defensin; beta 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    23-63
  • 氨基酸序列
    KKINNPVS CLRKGGRCWN RCIGNTRQIG SCGVPFLKCC KRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.
  • 基因功能参考文献：
    1. Thus, oral epithelial cells dominantly control IL-17R-dependent responses to oropharyngeal candidiasis through regulation of BD3 expression. PMID: 27923704
    2. C/EBPbeta contributes to immunity to mucosal candidiasis during cortisone immunosuppression in a manner linked to beta-defensin 3 expression, but is apparently dispensable for the IL-17-dependent response. PMID: 26317211
    3. Stress decreases mouse beta-defensin-3 expression in the esophagus of mice with diabetes. PMID: 24532508
    4. visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin. PMID: 23499548
    5. this investigation revealed an indispensable role for BD3, BD4, and CRAMP in defense against F. solani-induced keratitis PMID: 23670560
    6. Mouse beta-defensin 3 was strongly up-regulated in colonic epithelium of 15 (but not 5) week-old IL-2(-/-) mice and in dextran-sulfate-induced chronic (but not acute) colitis, but not in IL-2(+/-) 15-week-old mice. PMID: 21039426
    7. Epithelial and mucosal tissues expressed bd3 and recombinant bd3 exhibits antifungal activity. PMID: 20337925
    8. Murine beta-defensins BD2 and BD3 together promote resistance against corneal infection by Pseudomonas aeruginosa. PMID: 19933858
    9. Mycobacterial infection induces the expression of mBD3 and mBD4, and both might participate in the control of mycobacterial growth. PMID: 16897670
    10. The results indicate that BD-2 and -3 may be upregulated during the development of autoimmune sialoadenitis. PMID: 17874048
    11. The expression of BD3 was significantly elevated in the lungs of cigarette smoke-exposed mice compared with air-exposed mice. PMID: 18699806
    12. The results demonstrated that mouse beta-defensins possess anti-influenza virus activity, suggesting that mouse beta-defensins might be used as agents to prevent and treat influenza. PMID: 19301094

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-defensin family, LAP/TAP subfamily
  • 组织特异性：
    Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.
  • 数据库链接：

    KEGG: mmu:27358

    STRING: 10090.ENSMUSP00000033852

    UniGene: Mm.103651