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  4. Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4galnt2), partial

Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4galnt2), partial

  • 中文名称：
    Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2(B4galnt2),partial,Yeast
  • 货号：
    CSB-YP600603MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2(B4galnt2),partial,Yeast
  • 货号：
    CSB-EP600603MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2(B4galnt2),partial,Yeast
  • 货号：
    CSB-EP600603MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2(B4galnt2),partial,Yeast
  • 货号：
    CSB-BP600603MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-1,4 N-acetylgalactosaminyltransferase 2(B4galnt2),partial,Yeast
  • 货号：
    CSB-MP600603MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    B4galnt2
  • Uniprot No.：
  • 别名：
    B4galnt2; Galgt2; Ggm3Beta-1,4 N-acetylgalactosaminyltransferase 2; EC 2.4.1.-
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non-reducing terminal tetrasaccharide Sda blood group structure.
  • 基因功能参考文献：
    1. B4galnt2 displays an interesting spatial allelic distribution in Western Europe, likely due to the recent action of natural selection. PMID: 28806915
    2. Overexpression of Galgt2 failed to inhibit skeletal muscle pathology in dystroglycan-deficient muscles PMID: 26435413
    3. These data support a critical role for B4galnt2 in gastrointestinal infections PMID: 26133982
    4. Galgt2 is required for postsynaptic expression of the CT carbohydrate at the neuromuscular junction. PMID: 22982027
    5. We describe changes that result from overexpression of Galgt2, a normally synaptic muscle glycosyltransferase that can modify alpha dystroglycan and inhibit the development of muscular dystrophy when it is overexpressed. PMID: 22775139
    6. Study describes detailed characterization of mouse gastrointestinal bacterial communities in 7 distinct locations from the duodenum to the colon and provide evidence for a significant effect of B4galnt2 expression on intestinal bacterial populations. PMID: 22278669
    7. Data suggest that B4GALNT2 and Sd(a) antigen are essential for embryo implantation. PMID: 22401809
    8. Expression of B4galnt2 in pregnant mice is regulated by progesterone. The naturally occurring up-regulation of B4galnt2 during pregnancy contributes to normal embryo implantation. PMID: 21481371
    9. we show that overexpression of the cytotoxic T cell (CT) GalNAc transferase (Galgt2) is effective in inhibiting the development of muscle pathology in the dy(W) mouse model of MDC1A PMID: 17591965
    10. These experiments demonstrate that Galgt2 can control growth by modulating the expression of myostatin and myostatin inhibitors during particular periods of muscle development. PMID: 19086062
    11. low VWF levels may represent a fitness cost that is offset by a yet unknown benefit of the B4galnt2 tissue-specific switch. PMID: 19088380
    12. Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice. PMID: 19109526
    13. Galgt2 has therapeutic effects in three distinct forms of muscular dystrophy PMID: 19498002

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 数据库链接：

    KEGG: mmu:14422

    STRING: 10090.ENSMUSP00000037239

    UniGene: Mm.340702