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  4. Recombinant Mouse Aspartoacylase (Aspa)

Recombinant Mouse Aspartoacylase (Aspa)

  • 中文名称：
    Recombinant Mouse Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-YP844452MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-EP844452MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-EP844452MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-BP844452MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-MP844452MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AspaAspartoacylase; EC 3.5.1.15; Aminoacylase-2; ACY-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-312
  • 氨基酸序列
    MTSCVAKEPI KKIAIFGGTH GNELTGVFLV THWLRNGTEV HRAGLDVKPF ITNPRAVEKC TRYIDCDLNR VFDLENLSKE MSEDLPYEVR RAQEINHLFG PKNSDDAYDL VFDLHNTTSN MGCTLILEDS RNDFLIQMFH YIKTCMAPLP CSVYLIEHPS LKYATTRSIA KYPVGIEVGP QPHGVLRADI LDQMRKMIKH ALDFIQHFNE GKEFPPCSID VYKIMEKVDY PRNESGDMAA VIHPNLQDQD WKPLHPGDPV FVSLDGKVIP LGGDCTVYPV FVNEAAYYEK KEAFAKTTKL TLSAKSIRST LH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.
  • 基因功能参考文献：
    1. This study demonstrated that N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. PMID: 27717881
    2. Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages through aspartoacylase. PMID: 25024137
    3. aspartoacylase is proposed here to support lipid synthesis and energy metabolism via the provision of substrate for both cellular processes during early postnatal development PMID: 22617649
    4. Intracellular vacuolisation in astrocytes coincides with axonal swellings in cerebellum and brain stem of aspa(lacZ/lacZ) mutants indicating that astroglia may act as an osmolyte buffer in the aspa-deficient CNS PMID: 21625469
    5. Aspa defects were associated with increased levels of acetylated histone H3, decreased chromatin compaction and increased GFAP protein, a marker for astrogliosis. Early in postnatal development ASPA defic affects oligodendrocyte maturation and myelination PMID: 20637282
    6. Death of OLs, neurons, and astrocytes was identified in every region of the aspartoacylase KO brain. These findings support involvement of ASPA in CNS development and function. PMID: 19739253
    7. ASPA gene defect in the mouse leads to spinal cord pathology; these changes may be involved in the cause of the physiological/behavioral abnormalities seen in the knockout mouse. PMID: 15686967
    8. normal hydrolysis of N-acetylaspartic acid is affected by aspartoacylase activity seen in the type 2 diabetes model mouse PMID: 16707098
    9. we now present immunoblot, proteomic, and biochemical evidence that the membrane-bound form of ASPA is intrinsic to purified myelin membranes. PMID: 17254025
    10. Nur7( Q193X) is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. PMID: 18987190

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AspA/AstE family, Aspartoacylase subfamily
  • 数据库链接：

    KEGG: mmu:11484

    STRING: 10090.ENSMUSP00000021119

    UniGene: Mm.293574