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  4. Recombinant Mouse Asc-type amino acid transporter 1 (Slc7a10), partial

Recombinant Mouse Asc-type amino acid transporter 1 (Slc7a10), partial

In Stock
  • 中文名称：
    小鼠Slc7a10重组蛋白
  • 货号：
    CSB-YP021710MO
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Slc7a10
  • Uniprot No.：
  • 别名：
    Slc7a10; Asc1; Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    Yeast
  • 分子量：
    22.5kDa
  • 蛋白标签：
    N-terminal His-tagged/Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.
  • 基因功能参考文献：
    1. this study shows that the astrocytic transporter SLC7A10 mediates glycinergic inhibition of spinal cord motor neurons PMID: 27759100
    2. Asc-1 has a novel role in regulating NMDA receptor-dependent synaptic activity by mediating concurrent non-vesicular release of D-serine and glycine. PMID: 23426681
    3. The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission PMID: 25755256
    4. The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein. PMID: 25080478
    5. Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. PMID: 16026768
    6. The results presented reveal that Asc-1 is the only high affinity D-serine transporter in the mouse CNS and is the predominant mechanism for D-serine reuptake. PMID: 17432963

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily
  • 组织特异性：
    Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine.
  • 数据库链接：

    KEGG: mmu:53896

    STRING: 10090.ENSMUSP00000001854

    UniGene: Mm.35567