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  4. Recombinant Mouse Arylsulfatase A (Arsa)

Recombinant Mouse Arylsulfatase A (Arsa)

  • 中文名称：
    Recombinant Mouse Arylsulfatase A(Arsa),Yeast
  • 货号：
    CSB-YP002141MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Arylsulfatase A(Arsa),Yeast
  • 货号：
    CSB-EP002141MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Arylsulfatase A(Arsa),Yeast
  • 货号：
    CSB-EP002141MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Arylsulfatase A(Arsa),Yeast
  • 货号：
    CSB-BP002141MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Arylsulfatase A(Arsa),Yeast
  • 货号：
    CSB-MP002141MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Arsa; As2; Arylsulfatase A; ASA; EC 3.1.6.8; Cerebroside-sulfatase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-506
  • 氨基酸序列
    SPP NILLIFADDL GYGDLGSYGH PSSTTPNLDQ LAEGGLRFTD FYVPVSLCTP SRAALLTGRL PVRSGMYPGV LGPSSQGGLP LEEVTLAEVL AARGYLTGMA GKWHLGVGPE GAFLPPHQGF HRFLGIPYSH DQGPCQNLTC FPPDIPCKGG CDQGLVPIPL LANLTVEAQP PWLPGLEARY VSFSRDLMAD AQRQGRPFFL YYASHHTHYP QFSGQSFTKR SGRGPFGDSL MELDGAVGAL MTTVGDLGLL EETLVIFTAD NGPELMRMSN GGCSGLLRCG KGTTFEGGVR EPALVYWPGH ITPGVTHELA SSLDLLPTLA ALTGAPLPNV TLDGVDISPL LLGTGKSPRK SVFFYPPYPD EIHGVFAVRN GKYKAHFFTQ GSAHSDTTSD PACHAANRLT AHEPPLLYDL SQDPGENYNV LESIEGVSPE ALQALKHIQL LKAQYDAAMT FGPSQIAKGE DPALQICCQP SCTPHPVCCH CPGSQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes cerebroside sulfate.
  • 基因功能参考文献：
    1. Multipotential Neural precursors deficient in arylsulfatase A show a higher ratio of long versus short fatty acid sulfatides, reduction in PDGFRa, decreased AKT phosphorylation, and increased exosomal shedding of PDGFRa. PMID: 25605750
    2. distributed not only on the cell surfaces of endothelial cells and hepatocytes, but also on the collagen fibrils in the space of Disse PMID: 23883774
    3. Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner. PMID: 22685254
    4. Sulfogalactosylglycerolipid was a physiological substrate of Sertoli lysosomal arylsulfatase A PMID: 21965315
    5. study provides the first proof of cognitive deficit and impaired synaptic plasticity in an MLD mouse model. PMID: 21459117
    6. ArsA plays a role as a novel component of the extracellular matrix which could be very useful for clarifying the mechanisms underlying some of the syndromes caused by functional deficiency of the Ars genes. PMID: 20297902
    7. Data demonstrate a delay in myelin formation in ASA-deficient mice at 2 weeks of age, as a consequence of inability to degrade sulfatide. PMID: 15733089
    8. Since high cholesterol levels are important for myelination, and various cellular processes, like vesicular trafficking and signal transduction, reduced cholesterol levels might be an important factor in the molecular pathology of MLD. PMID: 16630546
    9. ASA-deficient [ASA(-/-)] mice overexpressing the sulfatide synthesizing enzymes causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy PMID: 17715338
    10. The increasing sulfatide storage in ASA(-/-) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD. PMID: 17728461
    11. Safety of Arsa overexpression for gene therapy of metachromatic leukodystrophy was evaluated. PMID: 17845130
    12. Lysosomal AS-A may be involved in cell-surface remodeling during luteolysis by desulfating SGG after its endocytosis and targeting to the lysosome. PMID: 18420734
    13. Saposin B(Sap B) is not a limiting factor of the coupled Sap B-ASA reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels PMID: 19224915

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  • 亚细胞定位：
    Endoplasmic reticulum. Lysosome.
  • 蛋白家族：
    Sulfatase family
  • 数据库链接：

    KEGG: mmu:11883

    STRING: 10090.ENSMUSP00000127646

    UniGene: Mm.620