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  4. Recombinant Mouse Angiopoietin-related protein 6 (Angptl6)

Recombinant Mouse Angiopoietin-related protein 6 (Angptl6)

  • 中文名称：
    Recombinant Mouse Angiopoietin-related protein 6(Angptl6),Yeast
  • 货号：
    CSB-YP837116MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiopoietin-related protein 6(Angptl6),Yeast
  • 货号：
    CSB-EP837116MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiopoietin-related protein 6(Angptl6),Yeast
  • 货号：
    CSB-EP837116MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Angiopoietin-related protein 6(Angptl6),Yeast
  • 货号：
    CSB-BP837116MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiopoietin-related protein 6(Angptl6),Yeast
  • 货号：
    CSB-MP837116MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Angptl6
  • Uniprot No.：
  • 别名：
    Angptl6; AgfAngiopoietin-related protein 6; Angiopoietin-like protein 6; Angiopoietin-related growth factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-457
  • 氨基酸序列
    ARCRVT LVLSPQKATS AVCRSSEATQ DSELATLRMR LGRHEELLRA LQRRAAEGGA LADEVRALRE HSLTLNTRLG QLRAQLQQEA RAEPDLGAEP AAALGLLAER ALDAEAEARR TTARLQQLDA QLREHAQLMS QHSSLLGRLQ RACAGPERGQ QQVLPLPLAP LVPLSLVGSA SNTSRRLDQT PEHQREQSLR QQGPPSSLLP TGHLAVPTRP VGPWRDCAEA HGAGHWQSGV YDLRLGRRVV AVWCEQQQEG GGWTVIQRRQ DGSVNFFTNW QHYKAGFGRP EGEYWLGLEP VHQVTSRGDH ELLILLEDWG GRAARAHYDS FSLEPESDHY RLRLGQYHGD AGDSLSWHND KPFSTVDRDR DSYSGNCALY HRGGWWYHAC AHSNLNGVWY HGGHYRSRYQ DGVYWAEFRG GAYSLKKAVM LTRLVRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
  • 基因功能参考文献：
    1. Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression. PMID: 29852166
    2. Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. PMID: 27698489
    3. mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 production in adipose tissue and cultured adipocytes. PMID: 28184000
    4. In addition to pronounced angiogenesis and epidermal hyperplasia, marked enlargement of dermal lymphatic vessels was observed in UV-B-exposed Angptl6/AGF transgenic mice. PMID: 22132739
    5. we show that (>80%) of the AGF-deficient mice die at about embryonic day 13, while the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin resistance accompanied by reduced energy expenditure PMID: 15778720
    6. Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism. PMID: 16806062
    7. Activation of an ERK1/2-eNOS-NO pathway is a crucial signaling mechanism by which angiopoietin-related growth factor increases blood flow through induction of angiogenesis and arteriogenesis. PMID: 18258819

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Highly expressed in the liver, specifically in hepatocytes, and weakly in the heart. Expressed in hematopoietic cells, platelets and mast cells, and detected at wounded skin.
  • 数据库链接：

    KEGG: mmu:70726

    STRING: 10090.ENSMUSP00000035784

    UniGene: Mm.34019