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  4. Recombinant Mouse Amine oxidase [flavin-containing] B (Maob), partial

Recombinant Mouse Amine oxidase [flavin-containing] B (Maob), partial

  • 货号：
    CSB-YP803947MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803947MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803947MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803947MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803947MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Maob; Amine oxidase [flavin-containing] B; EC 1.4.3.4; Monoamine oxidase type B; MAO-B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
  • 基因功能参考文献：
    1. Hydralazine (Hdz) abrogated the degradation of tele-methylhistamine (tMH) catalyzed by monoamine oxidase B (MAO-B) in vitro. PMID: 28069864
    2. Huntington disease neural cells exhibit increased Monoamine oxidase-A and Monoamine oxidases-B expression and activity PMID: 25398695
    3. Activity of monoamine oxidase B in the striatum is reduced during the presymptomatic stage, but returns to the control level during the symptomatic stage of Parkinsonism in mice. PMID: 26388575
    4. These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin secretion and that loss of MaoB expression may contribute to the beta cell dysfunction in type 2 diabetes. PMID: 26546820
    5. Monoamine oxidase B deficiency (along with monoamine oxidase A) resulted in an array of abnormalities similar to autism-spectrum disorder. PMID: 22850464
    6. chronic elevations of monoamines, because of the absence of MAO A and MAO B, cause functional alterations that are accompanied with changes in the cellular mechanisms underlying learning and memory. PMID: 23858446
    7. MAO-B is involved in the acute neurotoxicity of MPTP in embryonic and newborn mice PMID: 22281418
    8. Data suggest that both IR1 (imidazoline receptor 1) and IR2/Maob play roles in acquisition of behavioral responses in alcoholism; activation of IR1 and IR2/Maob may serve as molecular targets in prevention (and possibly treatment) of alcoholism. PMID: 23399882
    9. The results of our study further confirms that the dox-inducible astrocytic MAO-B transgenic mouse displays similar age-related behavioral and neuropathological features to other models of Parkinson's disease PMID: 23326597
    10. MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain PMID: 22771623
    11. The temporal sequence of events following MAO-B elevation initially involves increased oxidative stress followed by mitochondrial complex I inhibition and finally neurodegeneration. PMID: 20655384
    12. Data indicate that the activity of MAOB could modulate the regular and amphetamine-perturbed expression of GAD(67) and pCREB, and suggest interactions among the MAOB activity, GABA content of OlfB, and olfaction. PMID: 19902350
    13. The findings of this study revealed novel roles for MAO-b and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain. PMID: 20702706
    14. a monoamine-oxidase epigenetic regulation is involved in effects of smoking PMID: 19956754
    15. these results suggest that MAO B deficiency may lead to behavioral disinhibition and decreased anxiety-like responses partially through regional increases of Phenylethylamine levels. PMID: 19710633
    16. Observed chase/escape and anxiety-like behavior in the MAO A/B KO mice, different from MAO A or B single KO mice, suggest that varying monoamine levels result in both a unique biochemical and behavioral phenotype. PMID: 15272015
    17. Moreover, MAOB is region-dependently involved in responses of the brain to Amph and baclofen, supporting interactions between GABA and monoamines. PMID: 16983645
    18. Elevated astrocytic MAO-B mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra, accompanied by decreases in mt complex I activity and increased mt oxidative stress. PMID: 18286173
    19. data strongly suggest that, although MAO-B is highly expressed in focal freeze brain injury, its activity does not contribute to the cellular damage or play any role in regulating astrocytic reactivity PMID: 18831059

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 数据库链接：

    KEGG: mmu:109731

    STRING: 10090.ENSMUSP00000040550

    UniGene: Mm.241656