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  4. Recombinant Mouse Alpha-2-HS-glycoprotein (Ahsg)

Recombinant Mouse Alpha-2-HS-glycoprotein (Ahsg)

  • 中文名称：
    Recombinant Mouse Alpha-2-HS-glycoprotein(Ahsg),Yeast
  • 货号：
    CSB-YP001485MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-HS-glycoprotein(Ahsg),Yeast
  • 货号：
    CSB-EP001485MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-HS-glycoprotein(Ahsg),Yeast
  • 货号：
    CSB-EP001485MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-HS-glycoprotein(Ahsg),Yeast
  • 货号：
    CSB-BP001485MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-HS-glycoprotein(Ahsg),Yeast
  • 货号：
    CSB-MP001485MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ahsg
  • Uniprot No.：
  • 别名：
    Ahsg; FetuaAlpha-2-HS-glycoprotein; Countertrypin; Fetuin-A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-345
  • 氨基酸序列
    AP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN HLLQGFKQVL NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC SVRQLTEHAV EGDCDFHILK QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP LLTPFNDTNV VHTVNTALAA FNTQNNGTYF KLVEISRAQN VPLPVSTLVE FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG EEVSVACKLF QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Probably involved in differentiation.
  • 基因功能参考文献：
    1. Downregulation of adiponectin in inflamed adipocyte by fetuin-A through the mediation of Wnt3a and PPARgamma is a new report. PMID: 27720679
    2. FETUA expression and ER stress markers in the liver and serum of HFD mice were decreased by melatonin treatment. In conclusion, melatonin can improve hepatic insulin resistance and hepatic steatosis through reduction in ER stress and the resultant AHSG expression. PMID: 29607540
    3. Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A. PMID: 29030114
    4. The growth plate slippage occurred in 70% of Ahsg-/- mice of both sexes around three weeks postnatal. PMID: 29088242
    5. AHSG is produced in bone, mainly in osteocytes and also show for the first time that its production is modulated by FGF23. PMID: 26476373
    6. These findings establish urinary Fetuin-A as a sensitive biomarker of the progression of autosomal dominant polycystic kidney disease. PMID: 25888842
    7. Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls. PMID: 24994603
    8. fetuin-A regulates endochondral ossification through mineralization inhibition and lipid (hormone) binding [review] PMID: 23277412
    9. Our results show that CSF fetuin-A is a biomarker of disease activity and natalizumab response in multiple sclerosis PMID: 23439582
    10. lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization PMID: 23943623
    11. FetA, via its terminal galactoside moiety, directly binds Leu100-Gly123 & Thr493-Thr516 in Tlr4, fulfilling the requirement of an endogenous ligand for TLR4 through which lipids induce insulin resistance. PMID: 22842477
    12. Our results show that fetuin-A has a developmental rather than a structural role in murine bone. PMID: 23091616
    13. Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A. PMID: 22753077
    14. ER stress induced by high glucose and palmitate increases the expression of fetuin-A and further contributes to the development of insulin resistance PMID: 22619360
    15. fetuin-A is protective against lethal systemic inflammation partly by inhibiting active HMGB1 release PMID: 21347455
    16. Fetuin-A deficiency is associated with soft tissue calcification in mice and humans. PMID: 21659653
    17. breast cancer but also of other tumors whose initiation and promotion are under the tight control of TGF-beta. PMID: 20847285
    18. Fetuin-A expressions were negatively correlated with the liver pathological scores and TNFa levels in fulminant hepatic failure. PMID: 18578995
    19. alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling PMID: 11901155
    20. Improved insulin sensitivity and resistance to weight gain in knockout mice PMID: 12145157
    21. role as a systemically acting inhibitor of ectopic calcification PMID: 12897203
    22. Regulation of BMP-induced ectopic bone formation by Ahsg. PMID: 15885488
    23. Onset of malaria infection is delayed in fetuin-A-deficient mice compared to that in wild-type C57BL/6 mice challenged with Plasmodium berghei sporozoites PMID: 16113307
    24. Fetuin-A knockout (fetuin-KO) mice spontaneously develop widespread soft tissue calcification, including significant myocardial calcification, whereas larger arteries are spared. PMID: 16177000
    25. The absence of fetuin may contribute to the improvement of insulin sensitivity associated with aging. PMID: 17011519
    26. Fetuin-A deficiency, chronic kidney disease, and high phosphate diet act synergistically in the pathogenesis of extraosseous calcification. PMID: 17389622
    27. fetuin recognized by anti-LY-R antibodies is an immunogenic form associated only with the tumorigenic LY-R cells and might be involved in tumor progression in this lymphoma. PMID: 19194829
    28. inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis PMID: 19389852
    29. inhibition of ectopic calcification PMID: 12556469
    30. inhibition of ectopic calcification PMID: 9395485

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Fetuin family
  • 组织特异性：
    Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.
  • 数据库链接：

    KEGG: mmu:11625

    STRING: 10090.ENSMUSP00000023583

    UniGene: Mm.197554