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  4. Recombinant Human herpesvirus 6A Capsid-binding protein U65 (U65)

Recombinant Human herpesvirus 6A Capsid-binding protein U65 (U65)

  • 货号：
    CSB-YP332989HJZ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP332989HJZ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP332989HJZ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP332989HJZ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP332989HJZ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    U65
  • Uniprot No.：
  • 别名：
    U65; 11RCytoplasmic envelopment protein 2
  • 种属：
    Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-335
  • 氨基酸序列
    MAISTFSIGD LGYLRNFLQN ECNWFRICKK TFYREYRSVA TSSPTFSLNN KPKKFCMHCE IVIFKRSEEF MFSLAVNGIH FGQFLTGKMK FNKKAVPEGL YYYILELGSI TPIDLGFIPR YNSDCVTNMR CVTPEVIYEN CSIVCPEEAN RLTVKGSGDN KLTPLGGCGA WCLKNGGDLY IYTFALAYDL FLTCYDKSTF PSLAKIIFDM IACESEDCVF CKDHNKHVSQ AGQIVGCVSN QETCFCYTSC KKKMANINNP ELISLLCDQE INKIDIMYPK IKASLSLDIN SYAHGYFGDD PYALKCVNWI PVRISAALSR LIVLSCPVCK RVVMD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
  • 基因功能参考文献：
    1. U51 is a positive regulator of virus replication in vitro, perhaps because it may promote membrane fusion and facilitates cell-cell spread of this highly cell-associated virus. PMID: 16140767
    2. U51 can be considered a sensitive and versatile virally encoded signaling device, potentially of importance in HHV-6-related pathologies. PMID: 16332987
    3. U51A may affect virus dissemination or transmission by chemotaxis of infected cells to sites of chemokine secretion specific for U51A and evade immune-effector cells by chemokine diversion and down-regulation, affecting virus spread and inflammation. PMID: 18286574
  • 亚细胞定位：
    Virion tegument. Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Herpesviridae cytoplasmic envelopment protein 2 family
  • 数据库链接：

    KEGG: vg:1487947