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  4. Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5 (RL1)

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5 (RL1)

  • 货号：
    CSB-YP330571HWY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP330571HWY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP330571HWY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP330571HWY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP330571HWY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RL1
  • Uniprot No.：
  • 别名：
    ICP34.5; RL1Neurovirulence factor ICP34.5; Infected cell protein 34.5; protein gamma(1)34.5
  • 种属：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-248
  • 氨基酸序列
    MARRRRHRGP RRPRPPGPTG AVPTAQSQVT STPNSEPAVR SAPAAAPPPP PAGGPPPSCS LLLRQWLHVP ESASDDDDDD DWPDSPPPEP APEARPTAAA PRPRPPPPGV GPGGGADPSH PPSRPFRLPP RLALRLRVTA EHLARLRLRR AGGEGAPEPP ATPATPATPA TPATPARVRF SPHVRVRHLV VWASAARLAR RGSWARERAD RARFRRRVAE AEAVIGPCLG PEARARALAR GAGPANSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays essential roles in viral nuclear egress to mediate capsid transit across the nuclear membrane and also in the inhibition of host immune response. Facilitates nuclear egress cooperatively with host C1QBP and protein kinase C/PKC to induce lamin A/C phosphorylation and subsequent reorganization. In turn, lamina disassembles and nuclear egress occurs. Recruits the serine/threonine protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. In turn, controls host IRF3 activation and subsequently inhibits host interferon response. Controls the DNA sensing pathway by interacting with and inhibiting host STING/TMEM173. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, by interqcting with host BECN1 and thereby antagonizing the host autophagy response.
  • 亚细胞定位：
    Host cytoplasm. Host nucleus. Host nucleus, host nucleolus. Virion.
  • 蛋白家族：
    PPP1R15 family
  • 数据库链接：

    KEGG: vg:2703395