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  4. Recombinant Human cytomegalovirus Protein UL76 (UL76)

Recombinant Human cytomegalovirus Protein UL76 (UL76)

  • 中文名称：
    Recombinant Human cytomegalovirus Protein UL76(UL76),Yeast
  • 货号：
    CSB-YP744213HWW
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human cytomegalovirus Protein UL76(UL76),Yeast
  • 货号：
    CSB-EP744213HWW
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human cytomegalovirus Protein UL76(UL76),Yeast
  • 货号：
    CSB-EP744213HWW-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human cytomegalovirus Protein UL76(UL76),Yeast
  • 货号：
    CSB-BP744213HWW
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human cytomegalovirus Protein UL76(UL76),Yeast
  • 货号：
    CSB-MP744213HWW
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UL76
  • Uniprot No.：
  • 别名：
    UL76; Protein UL76
  • 种属：
    Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-325
  • 氨基酸序列
    MPSGCGDDAD STGNALRRLP HVRKRIGKRK HLDIYRRLLR VFPSFVALNR LLGGLFPPEL QKYRRRLFIE VRLSRRIPDC VLVFLPPDSG SRGIVYCYVI EFKTTYSDAD DQSVRWHATH SLQYAEGLRQ LKGALVDFDF LRLPRGGGQV WSVVPSLVFF QQKADRPSFY RAFRSGRFDL CTDSVLDYLG RRQDESVAHL LAATRRRLLR AARGKRAALP RARASAVAGG RGGGNARRGL ARGRAHGPGA QTVSASGAEG SGSQGTDLLR GSRRARVRGG GAVEPAVRAR RRTVAADAAT TTVSSAFVVP RDRRGRSFRR PTRSL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL76 supposedly acts on this process through its effect on host nucleoli. Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclinB/CDK1.
  • 基因功能参考文献：
    1. findings suggest that the unconserved C terminal (not the conserved N terminal) of pUL76 was sufficient to induce DNA damage and aggresome formation in transfected cells. PMID: 26494186
    2. Data suggest that expression of cytomegalovirus UL76 up-regulates human interleukin-8 (IL8) expression/secretion in response to DNA damage; both UL76 and human ATM kinase have roles in mechanism of IL8 induction during cytomegalovirus infection. PMID: 24068928
    3. s demonstrate that human cytomegalovirus UL76 induces a novel nuclear aggresome, likely by subverting S5a of the ubiquitin-proteasome system. PMID: 23966401
    4. While UL76 is not essential for viral replication, the UL76 ORF is involved in regulation of the level of UL77 protein expression in a manner dependent on the translation re-initiation. PMID: 20689582
  • 亚细胞定位：
    Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
  • 蛋白家族：
    Herpesviridae UL24 family
  • 数据库链接：

    KEGG: vg:3077435