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  4. Recombinant Human adenovirus C serotype 2 Maturation protein (PIVA2)

Recombinant Human adenovirus C serotype 2 Maturation protein (PIVA2)

  • 货号：
    CSB-YP355998HIK
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP355998HIK
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP355998HIK-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP355998HIK
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP355998HIK
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IVa2
  • Uniprot No.：
  • 别名：
    IVa2; Packaging protein 1; Packaging protein IVa2
  • 种属：
    Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-449
  • 氨基酸序列
    METRGRRPAA LQHQQDQPQA HPGQRAARSA PLHRDPDYAD EDPAPVERHD PGPSGRAPTT AVQRKPPQPA KRGDMLDRDA VEHVTELWDR LELLGQTLKS MPTADGLKPL KNFASLQELL SLGGERLLAH LVRENMQVRD MLNEVAPLLR DDGSCSSLNY QLQPVIGVIY GPTGCGKSQL LRNLLSSQLI SPTPETVFFI APQVDMIPPS ELKAWEMQIC EGNYAPGPDG TIIPQSGTLR PRFVKMAYDD LILEHNYDVS DPRNIFAQAA ARGPIAIIMD ECMENLGGHK GVSKFFHAFP SKLHDKFPKC TGYTVLVVLH NMNPRRDMAG NIANLKIQSK MHLISPRMHP SQLNRFVNTY TKGLPLAISL LLKDIFRHHA QRSCYDWIIY NTTPQHEALQ WCYLHPRDGL MPMYLNIQSH LYHVLEKIHR TLNDRDRWSR AYRARKTPK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
  • 基因功能参考文献：
    1. IVa2, 33K and DBP form a complex at a unique vertex on viral capsids and cooperate in genome packaging. PMID: 23388198
    2. The s conclude that the major role of IVa2 is in viral DNA packaging. PMID: 21450831
  • 亚细胞定位：
    Virion. Host nucleus, host nucleoplasm. Host nucleus, host nucleolus.
  • 蛋白家族：
    Adenoviridae packaging protein 1 family
  • 数据库链接：

    KEGG: vg:5739974