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  4. Recombinant Human Vesicular integral-membrane protein VIP36 (LMAN2), partial

Recombinant Human Vesicular integral-membrane protein VIP36 (LMAN2), partial

  • 中文名称：
    人LMAN2重组蛋白
  • 货号：
    CSB-YP619640HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LMAN2重组蛋白
  • 货号：
    CSB-EP619640HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LMAN2重组蛋白
  • 货号：
    CSB-EP619640HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LMAN2重组蛋白
  • 货号：
    CSB-BP619640HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C5orf8; Glycoprotein GP36b; GP36B; Lectin mannose-binding 2; Lectin, mannose binding 2; LMAN 2; LMAN2; LMAN2_HUMAN; Vesicular integral membrane protein VIP36; Vesicular integral-membrane protein 36; Vesicular integral-membrane protein VIP36; VIP36
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.
  • 基因功能参考文献：
    1. data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively. PMID: 27765817
    2. Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C to fold and bind ligand. PMID: 23269669
    3. Results identify the glycoprotein alpha1-antitrypsin as a cargo of VIP36. PMID: 20477988
    4. VIP36 interacts with molecular chaperone BiP and has a role in the quality control of secretory proteins PMID: 17586539
    5. selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence. PMID: 18025080
    6. Live imaging of the canine homologous protein. PMID: 11359937

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  • 亚细胞定位：
    Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 16986

    OMIM: 609551

    KEGG: hsa:10960

    STRING: 9606.ENSP00000303366

    UniGene: Hs.75864