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  4. Recombinant Human Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B), partial

Recombinant Human Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B), partial

  • 中文名称：
    人VTI1B重组蛋白
  • 货号：
    CSB-YP887014HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人VTI1B重组蛋白
  • 货号：
    CSB-EP887014HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人VTI1B重组蛋白
  • 货号：
    CSB-BP887014HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人VTI1B重组蛋白
  • 货号：
    CSB-MP887014HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VTI1B
  • Uniprot No.：
  • 别名：
    HGNC:17793; V SNARE; v-SNARE; Vesicle associated soluble NSF attachment protein receptor; Vesicle transport through interaction with t SNAREs 1B; Vesicle transport through interaction with t SNAREs homolog 1B (yeast); Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; VTI1; VTI1 like; Vti1 rp1; VTI1-LIKE; Vti1-rp1; VTI1B; VTI1B_HUMAN; VTI1L; VTI1L1; VTI2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
  • 基因功能参考文献：
    1. Vti1b-dependent tethering of Lytic granule and CD3-endo determines accumulation, docking, and efficient lytic granule secretion at the immunological synapse. PMID: 21562157
    2. Results suggest that the combinational SNARE proteins VAMP8 and Vti1b mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation. PMID: 20089838
    3. A dual mechanism controlling the localization and function of exocytic v-SNAREs. PMID: 12853575
    4. Ca(2+) dissociates the Hrs-containing complex but not the VAMP-2-containing SNARE complex PMID: 14769786
    5. epsin 4 epsin-related protein is an adaptor for vti1b PMID: 15371541
    6. Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR. PMID: 18570918

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  • 亚细胞定位：
    Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule. Recycling endosome membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    VTI1 family
  • 组织特异性：
    Expressed in all tissues examined.
  • 数据库链接：

    HGNC: 17793

    OMIM: 603207

    KEGG: hsa:10490

    STRING: 9606.ENSP00000450731

    UniGene: Hs.741177