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  4. Recombinant Human UPF0536 protein C12orf66 (C12orf66)

Recombinant Human UPF0536 protein C12orf66 (C12orf66)

  • 中文名称：
    Recombinant Human UPF0536 protein C12orf66(C12orf66),Yeast
  • 货号：
    CSB-YP836259HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human UPF0536 protein C12orf66(C12orf66),Yeast
  • 货号：
    CSB-EP836259HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human UPF0536 protein C12orf66(C12orf66),Yeast
  • 货号：
    CSB-EP836259HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human UPF0536 protein C12orf66(C12orf66),Yeast
  • 货号：
    CSB-BP836259HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human UPF0536 protein C12orf66(C12orf66),Yeast
  • 货号：
    CSB-MP836259HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C12orf66
  • Uniprot No.：
  • 别名：
    C12orf66KICSTOR complex protein C12orf66
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-445
  • 氨基酸序列
    MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS WLSLLAALAH LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE LKKVVTGRGA LGGTAPHVEE LLSHLSEQLC FFVQARMEMA DFYEKMYTLS TQKFINAEEL VGLLDAIMKK YSSRFHHPIL SPLESSFQLE VDVLCHLLKA QAQVSEWKFL PSLVNLHSAH TKLQTWGQIF EKQRETKKHL FGGQSQKAVQ PPHLFLWLMK LKNMLLAKFS FYFHEALSRQ TTASEMKTLT AKANPDFFGK ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV SLPSDRPVMH WPNVIMIMTD RTSDLNSLEK VVHFYDDKVQ STYFLTRPEP HFTIVIIFES KKSERDSHFI SFLNEVSLAL KNPKVFASLK PGAKG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
  • 亚细胞定位：
    Lysosome membrane.
  • 蛋白家族：
    UPF0536 family
  • 数据库链接：

    HGNC: 26517

    OMIM: 617420

    KEGG: hsa:144577

    STRING: 9606.ENSP00000381132

    UniGene: Hs.444671