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  4. Recombinant Human Tumor necrosis factor receptor superfamily member 27 (EDA2R), partial

Recombinant Human Tumor necrosis factor receptor superfamily member 27 (EDA2R), partial

  • 中文名称：
    人EDA2R重组蛋白
  • 货号：
    CSB-YP881011HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EDA2R重组蛋白
  • 货号：
    CSB-EP881011HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EDA2R重组蛋白
  • 货号：
    CSB-EP881011HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EDA2R重组蛋白
  • 货号：
    CSB-BP881011HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EDA2R重组蛋白
  • 货号：
    CSB-MP881011HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EDA2R
  • Uniprot No.：
  • 别名：
    9430060M22Rik; Ectodysplasin A2 isoform receptor; Ectodysplasin A2 receptor; EDA A2R; EDA-A2 receptor; EDA2R; EDAA2R; MGC124099; OTTMUSP00000019574; OTTMUSP00000019575; RP23-188N15.1; TNFRSF27; TNR27_HUMAN; Tumor necrosis factor receptor superfamily member 27; Tumor necrosis factor receptor superfamily member XEDAR; X linked ectodysplasin A2 receptor; X linked ectodysplasin receptor; X-linked ectodysplasin-A2 receptor; XEDAR
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
  • 基因功能参考文献：
    1. We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X. PMID: 27060448
    2. EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation. PMID: 26659383
    3. XEDAR activates the non-canonical NF-kappaB pathway. PMID: 26260321
    4. To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs. PMID: 23959643
    5. The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss PMID: 22309448
    6. association in dental crowding in the Hong Kong Chinese population PMID: 21724072
    7. A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway. PMID: 20501644
    8. because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R PMID: 20199557
    9. Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation. PMID: 12270937
    10. XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion PMID: 15280356
    11. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
    12. The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia. PMID: 18385763
    13. androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness PMID: 19373488
    14. XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. PMID: 19543321

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  • 亚细胞定位：
    Membrane; Single-pass type III membrane protein.
  • 数据库链接：

    HGNC: 17756

    OMIM: 300276

    KEGG: hsa:60401

    UniGene: Hs.302017