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  4. Recombinant Human Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3)

Recombinant Human Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3)

  • 中文名称：
    人TNFAIP8L3重组蛋白
  • 货号：
    CSB-YP691848HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TNFAIP8L3重组蛋白
  • 货号：
    CSB-EP691848HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TNFAIP8L3重组蛋白
  • 货号：
    CSB-EP691848HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TNFAIP8L3重组蛋白
  • 货号：
    CSB-BP691848HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TNFAIP8L3重组蛋白
  • 货号：
    CSB-MP691848HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TNFAIP8L3
  • Uniprot No.：
  • 别名：
    TNFAIP8L3; TIPE3; Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-292
  • 氨基酸序列
    MGKPRQNPST LVSTLCEAEP KGKLWVNGYA GTQGTRDATL QTRLIPLSFH LQRGKGLAAP LSALSAPRLP ERPADGRVAV DAQPAARSMD SDSGEQSEGE PVTAAGPDVF SSKSLALQAQ KKILSKIASK TVANMLIDDT SSEIFDELYK VTKEHTHNKK EAHKIMKDLI KVAIKIGILY RNNQFSQEEL VIVEKFRKKL NQTAMTIVSF YEVEYTFDRN VLSNLLHECK DLVHELVQRH LTPRTHGRIN HVFNHFADVE FLSTLYSLDG DCRPNLKRIC EGINKLLDEK VL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
  • 基因功能参考文献：
    1. In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. (Meta-analysis) PMID: 29422769
    2. TIPE3 downregulation correlates with its CpG island hypermethylation in several solid cancers. TIPE3 acts as a tumor suppressor in nasopharyngeal carcinoma (NPC), providing a further insight into NPC progression and representing a potential prognostic biomarker for NPC PMID: 30217224
    3. High TIPE3 expression in the plasma membrane is associated with non-small-cell lung cancer. PMID: 29510688
    4. TIPE3 protein was upregulated in breast cancer tissues and positively correlated to invasion and metastasis of human breast cancer cells by activating AKT and NF-kappaB signaling pathways. PMID: 28388580
    5. Further MD simulations confirmed the dynamic stability of these lipids in the TH domain. This computational analysis thus provides insight into the binding mode of phospholipids in the TH domain of the TIPE family of proteins. PMID: 27783229
    6. TIPE3 protein is highly expressed in most human carcinoma cell lines. These results suggest that TIPE3 may play important roles in carcinogenesis and cell secretion. PMID: 25479791
    7. human cancers have markedly upregulated TIPE3 expression. Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3 expression enhances it in vivo PMID: 25242044

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    TNFAIP8 family
  • 组织特异性：
    Widely expressed (at protein level). Highly expressed in most carcinoma cell lines.
  • 数据库链接：

    HGNC: 20620

    OMIM: 616438

    KEGG: hsa:388121

    UniGene: Hs.306343