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  4. Recombinant Human Transmembrane 9 superfamily member 4 (TM9SF4), partial

Recombinant Human Transmembrane 9 superfamily member 4 (TM9SF4), partial

  • 中文名称：
    人TM9SF4重组蛋白
  • 货号：
    CSB-YP849762HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TM9SF4重组蛋白
  • 货号：
    CSB-EP849762HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TM9SF4重组蛋白
  • 货号：
    CSB-EP849762HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TM9SF4重组蛋白
  • 货号：
    CSB-BP849762HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TM9SF4重组蛋白
  • 货号：
    CSB-MP849762HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TM9SF4
  • Uniprot No.：
  • 别名：
    KIAA0255; TM9S4_HUMAN; Tm9sf4; Transmembrane 9 superfamily member 4; Transmembrane 9 superfamily protein member 4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells.
  • 基因功能参考文献：
    1. TM9SF4 is a direct target of HIF-1alpha, down-regulated in leukemic cells by hypoxia and involved in cell adhesion. PMID: 25961573
    2. Our study shows for the first time the important role of TM9SF4 in the aberrant constitutive activation of the V-ATPase, and the development of a malignant phenotype. PMID: 25659576
    3. TM9SF4 is a new marker of malignancy, representing a potential new target for anti-tumour strategies with a specific role in tumour cannibalism and in the establishment of a metastatic phenotype. PMID: 19893578
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Golgi apparatus. Early endosome.
  • 蛋白家族：
    Nonaspanin (TM9SF) (TC 9.A.2) family
  • 组织特异性：
    Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiat
  • 数据库链接：

    HGNC: 30797

    OMIM: 617727

    KEGG: hsa:9777

    STRING: 9606.ENSP00000381104

    UniGene: Hs.654665