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  4. Recombinant Human Transcription factor SOX-11 (SOX11)

Recombinant Human Transcription factor SOX-11 (SOX11)

  • 货号：
    CSB-YP022419HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022419HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022419HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022419HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022419HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    MRD27; SOX11; SOX11_HUMAN; SRY (sex determining region Y) box 11; SRY related HMG box gene 11; SRY-box 11; Transcription factor SOX-11
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-441
  • 氨基酸序列
    MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron. Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
  • 基因功能参考文献：
    1. Data demonstrate a key role for SOX11 in normal kidney development and may suggest that variants in this gene predispose to CAKUT. PMID: 29459093
    2. miR-223 was found to be negatively correlated with the mRNA level of SOX11 in clinical samples. Our work demonstrates for the first time that miR-223 is repressed and correlated with high-risk clinical features in MCL, which provides a potential molecule to target to optimize MCL management. PMID: 29158064
    3. SOX11 hypermethylation was associated with adverse clinicopathological characteristics of prostate cancer PMID: 29315911
    4. Our results confirm high specificity of SOX11 expression as a molecular marker for minimal residual disease in mantle cell lymphoma PMID: 29520657
    5. Both SOX11 and TFE3 were overexpressed in solid-pseudopapillary neoplasms (SPNs) and may be involved in the pathogenesis. PMID: 29272888
    6. Studied the association between miR-211-5p and SOX11 in regards to proliferation, viability, and invasion of human thyroid cancer (TC) cells. Found miR-211-5p was upregulated and SOX11 was downregulated in TC tissues and cell lines, and found By inhibiting SOX11, miR-211- 5p suppressed the proliferation and invasion of the TC cells. PMID: 28703321
    7. REVIEW: addresses the implication of SOX11 overexpression and frequent genetic lesions, cooperating with cyclin D1 underlying the pathogenesis of mantle cell lymphoma PMID: 28466437
    8. our work casts new light on the biology of mantle cell lymphoma (MCL), revealing the role of SOX11 exerting a functional effect through the repression of BCL6 transcription in MCL cells PMID: 26710884
    9. Study showed for the first time that HIG-2 and SOX11 mutually co-regulate each other, and that HIG-2 and SOX11 knock-down promote increased proliferation in a non-synergistic manner in primary mantle cell lymphoma cells. PMID: 26757780
    10. Solid pseudopapillary neoplasms (SPNs) showed positive staining for SRY-related high-mobility group box 11 (SOX-11), transcription factor E3 (TFE3) and beta-catenin on cell blocks. PMID: 29045075
    11. SOX11 (sex determining region Y-box 11) was inversely expressed with miR-223-3p in ovarian cancer (OC) cell lines and tissue specimens. miR-223-3p mimic decreased SOX11 expression. Overexpressing SOX11 inhibited ovarian cancer cell proliferation and invasion, which indicated that miR-223-3p regulated OC cell proliferation and invasion through targeting SOX11 expression. PMID: 28587313
    12. Our studies demonstrate that SOX11 is a critical regulator of multiple basal-like breast cancer phenotypes, including growth, migration, invasion, and expression of signature basal-like breast cancer genes PMID: 26894864
    13. findings suggest that SOX11 is a potential biomarker for ductal carcinoma in situ lesions containing cells harbouring distinct biological features that are likely to progress to invasive breast cancer. PMID: 28707729
    14. SOX11 antigen can be reliably detected in decalcified tissue bone marrow tissue from mantle cell lymphoma patients. PMID: 27720733
    15. results suggest that SOX11 promotes MCL homing and invasion and increases CAM-DR through the direct regulation of CXCR4 and FAK expression and FAK/PI3K/AKT pathway activation, contributing to a more aggressive phenotype. PMID: 28533307
    16. Analysis of 28 other patients with CHARGE showed no SOX11 copy number changes or pathogenic sequence variants. To our knowledge, this child's chromosomal abnormality is unique and represents the first co-occurrence of duplication 2p25 and clinical features of CHARGE syndrome PMID: 26850571
    17. SOX11 immunohistochemistry could be a useful adjunct in distinguishing secondary cutaneous mantle cell lymphoma from primary cutaneous B-cell lymphomas. PMID: 26762898
    18. BLIMP1 and XBP1 expression was also significantly more frequent in SOX11-negative than in -positive cases PMID: 26360498
    19. SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma PMID: 22642745
    20. SOX11 deletion or mutation can present with a Coffin-Siris phenotype PMID: 26543203
    21. The ability of sox11 to reduce effector caspase activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 PMID: 26505998
    22. Results show that in non-malignant cells, SOX11 is strongly marked by enrichment of H3K27me3 while tumors in general show promoter DNA methylation. PMID: 25880212
    23. The utility of mRNA analysis in defining SOX11 expression levels in mantle cell lymphoma and reactive lymph nodes. PMID: 25887497
    24. implementing detection of SOX11 in diagnostic flow cytometry would be beneficial for accurate and reliable diagnosis of MCL, especially for distinguishing cases of MCL and B-CLL/SLL with aberrant immune phenotypes PMID: 25120048
    25. Our results indicate that aberrant SOX11 gene promoter methylation may underlie its down-regulation in Gastric cancer PMID: 25801783
    26. The results of this study suggest that differential miRNA expression in neurons could contribute to an altered function of the transcription factor SOX11 and other genes in the setting of epilepsy PMID: 25766675
    27. SOX11 overexpression suppresses PCa cell migration and invasion. In conclusion, our findings demonstrate that SOX11 could suppress cell proliferation, migration, and invasion of PCa in vitro. PMID: 25773392
    28. These results suggest SOX11 as a possible biomarker that adds new biological information that could contribute to a better understanding of this pathology PMID: 25608839
    29. De novo SOX11 mutations cause Coffin-Siris syndrome. Sox11 is expressed in fetal brain and adult brain and heart tissue. PMID: 24886874
    30. Currently, there are contradictions regarding the association of SOX11 gene expression and outcome in MCL, while some s have related the lack of SOX11 expression with good prognosis, others find it associated with an adverse clinical course. PMID: 24736261
    31. SOX11 directly binds to genes in critical intracellular pathways controlling cell cycle and proliferation in MCL. PMID: 24681958
    32. High nuclear SOX11 expression to be associated with more prolonged overall survival. PMID: 25041022
    33. High SOX11 expression is associated with mantle cell lymphoma. PMID: 25056830
    34. PDGFA is a SOX11 direct target gene upregulated in MCL cells whose inhibition impaired SOX11-enhanced in vitro angiogenic effects on endothelial cells PMID: 25092176
    35. IHC revealed protein expression of all four genes. IHC staining for ADAM12, FAP, and WISP1 correlated with CDR and was higher, whereas SOX11 staining was lower in tumors with earlier recurrence following excision PMID: 24402778
    36. Results show that SOX11 is a potential tumor-suppressor and an independent positive prognostic factor in gastric cancer patients with less advanced clinicopathological features. PMID: 24604109
    37. This is the first report stating that quantification of SOX11 can be used as an minimal residual disease marker equal to the key translocation t(11;14) in Mantle cell lymphoma. PMID: 24878000
    38. patients with SOX11 expression showed a shorter TTT and SOX11-expressing MCL patients showed probably a more indolent course, but further analyses within a larger cohort are warranted to prove the independent diagnostic role of SOX11 expression PMID: 23648671
    39. SOX11 is overexpressed in cutaneous malignant melanoma patients. PMID: 23867449
    40. Characterize the new monoclonal anti-SOX11 antibodies, suitable for Western blot assay and immunohistochemistry. PMID: 24145648
    41. SOX11 is not able to identify mantle cell lymphoma from B-cell non-Hodgkin lymphomas PMID: 24225745
    42. There was statistically significant differences in SOX11 mRNA expression between mantle cell lymphoma and other B-cell non-Hodgkin lymphomas. PMID: 22967417
    43. The importance of Sox11 expression as a favourable prognosticator in glioblastomas. PMID: 23619925
    44. We confirm the importance of SOX11 as a diagnostic antigen in MCL as 100% of tissue micro array (TMA) cases show bright nuclear staining, using the SOX11-C1 antibody in IHC-P. PMID: 22738398
    45. SOX11 contributes to tumor development by altering the terminal B-cell differentiation program of mantle cell lymphoma. PMID: 23321250
    46. Downregulation of SOX11 is associated with neurodevelopmental defects in trisomies 21. PMID: 22752091
    47. significant difference between the expression levels of SOX11 in patients with mantle cell lymphoma at diagnosis (n = 21) and in healthy donors (n = 18) (blood: P < 0.0001; marrow: P = 0.0001) PMID: 22827557
    48. observations suggest the idea that MCL with mutated IGHV, SOX11-negativity, and nonnodal presentation correspond to a subtype of the disease with more indolent behavior PMID: 22915760
    49. High expression of SOX11 is associated with mantle cell lymphoma. PMID: 21479697
    50. In vitro studies demonstrated a SOX11-dependent regulation of mantle cell lymphoma - specific gene expression. PMID: 21880559

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  • 相关疾病：
    Mental retardation, autosomal dominant 27 (MRD27)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle.
  • 数据库链接：

    HGNC: 11191

    OMIM: 600898

    KEGG: hsa:6664

    STRING: 9606.ENSP00000322568

    UniGene: Hs.432638