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  4. Recombinant Human Transcription factor LBX1 (LBX1)

Recombinant Human Transcription factor LBX1 (LBX1)

  • 中文名称：
    人LBX1重组蛋白
  • 货号：
    CSB-YP012777HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LBX1重组蛋白
  • 货号：
    CSB-EP012777HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LBX1重组蛋白
  • 货号：
    CSB-EP012777HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LBX1重组蛋白
  • 货号：
    CSB-BP012777HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LBX1重组蛋白
  • 货号：
    CSB-MP012777HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LBX1
  • Uniprot No.：
  • 别名：
    LBX1; LBX1H; Transcription factor LBX1; Ladybird homeobox protein homolog 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-281
  • 氨基酸序列
    MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL QLSPASPLTD QPASSQDCSE DEEDEEIDVD D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
  • 基因功能参考文献：
    1. Two single nucleotide polymorphisms around LBX1 are associated with adolescent idiopathic scoliosis in a Northern Chinese Han population. PMID: 28187071
    2. Meta-analysis provides evidence that rs111090870, rs678741 and rs625039 polymorphisms near LBX1 gene are associated with adolescent idiopathic scoliosis susceptibility in some populations.[meta-analysis] PMID: 27450593
    3. LBX1 is a susceptibility gene for idiopathic scoliosis in a Scandinavian population. PMID: 25987191
    4. In embryos overexpressing lbx1b, wnt5b, a ligand of the non-canonical Wnt/planar cell polarity (PCP) pathway, was significantly downregulated. PMID: 26820155
    5. Our results identify two clinically relevant haplotypes in the LBX1-region with opposite effects on AIS risk. PMID: 25675428
    6. Based on meta-analysis rs11190870 near LBX1 is likely a susceptibility variant for adolescent idiopathic scoliosis in East Asians. PMID: 24878781
    7. Performed a meta-analysis of the LBX1 locus in six Asian and three non-Asian cohorts of adolescent idiopathic scoliosis (AIS) and found significant evidence for association of this locus with AIS susceptibility in all nine cohorts. PMID: 24721834
    8. The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of adolescent idiopathic scoliosis in Han Chinese adolescents. PMID: 23096252
    9. This study shows that the genetic variants near the LBX1 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese Han population. PMID: 23308168
    10. Single nucleotide polymorphism near LBX1 is significantly associated with adolescent idiopathic scoliosis in southern Chinese. PMID: 22301463
    11. A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis PMID: 22019779
    12. Ladybird homeobox 1 (LBX1), a developmentally regulated homeobox gene, directs expression of the known EMT inducers ZEB1, ZEB2, Snail1, and transforming growth factor beta2 (TGFB2). PMID: 19651985

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16960

    OMIM: 604255

    KEGG: hsa:10660

    STRING: 9606.ENSP00000359212

    UniGene: Hs.37128