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  4. Recombinant Human Three prime repair exonuclease 2 (TREX2)

Recombinant Human Three prime repair exonuclease 2 (TREX2)

  • 中文名称：
    人TREX2重组蛋白
  • 货号：
    CSB-YP860654HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TREX2重组蛋白
  • 货号：
    CSB-EP860654HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TREX2重组蛋白
  • 货号：
    CSB-EP860654HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TREX2重组蛋白
  • 货号：
    CSB-BP860654HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TREX2重组蛋白
  • 货号：
    CSB-MP860654HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TREX2
  • Uniprot No.：
  • 别名：
    3' 5' exonuclease; 3' 5' exonuclease TREX2; 3'-5' exonuclease TREX2; Three prime repair exonuclease 2; TREX 2; TREX2; TREX2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-279
  • 氨基酸序列
    MGRAGSPLPR SSWPRMDDCG SRSRCSPTLC SSLRTCYPRG NITMSEAPRA ETFVFLDLEA TGLPSVEPEI AELSLFAVHR SSLENPEHDE SGALVLPRVL DKLTLCMCPE RPFTAKASEI TGLSSEGLAR CRKAGFDGAV VRTLQAFLSR QAGPICLVAH NGFDYDFPLL CAELRRLGAR LPRDTVCLDT LPALRGLDRA HSHGTRARGR QGYSLGSLFH RYFRAEPSAA HSAEGDVHTL LLIFLHRAAE LLAWADEQAR GWAHIEPMYL PPDDPSLEA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
  • 基因功能参考文献：
    1. Altogether, data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response. PMID: 26090614
    2. human TREX-2 complex prevents genome instability, as determined by the accumulation of gamma-H2AX and 53BP1 foci and single-cell electrophoresis in cells depleted of the TREX-2 subunits PCID2, GANP and DSS1 PMID: 24896180
    3. TREX-2 is an NPC-associated complex in mammalian cells. PMID: 23591820
    4. Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes. PMID: 21546543
    5. Polymorphisms exist in prostatic cancer patients. PMID: 15581481
    6. analysis of human TREX2 3' -> 5'-exonuclease structure and description of the mechanism for efficient nonprocessive DNA catalysis PMID: 15661738
    7. Results suggest that TREX2 plays an important function during DNA metabolism and cellular proliferation. PMID: 17426129
    8. analysis of cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease PMID: 18534978
    9. Trex2 deletion caused high levels of Robertsonian translocations (RbTs) showing Trex2 is important for chromosomal maintenance. PMID: 19094998
    10. a model for DNA binding and 3' hydrolysis for the TREX2 dimer. PMID: 19321497

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Exonuclease superfamily, TREX family
  • 组织特异性：
    Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
  • 数据库链接：

    HGNC: 12270

    OMIM: 300370

    KEGG: hsa:11219

    STRING: 9606.ENSP00000333441

    UniGene: Hs.644635