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  4. Recombinant Human Testis-specific gene 10 protein (TSGA10)

Recombinant Human Testis-specific gene 10 protein (TSGA10)

  • 中文名称：
    人TSGA10重组蛋白
  • 货号：
    CSB-YP863172HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TSGA10重组蛋白
  • 货号：
    CSB-EP863172HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TSGA10重组蛋白
  • 货号：
    CSB-EP863172HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TSGA10重组蛋白
  • 货号：
    CSB-BP863172HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TSGA10重组蛋白
  • 货号：
    CSB-MP863172HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TSGA10
  • Uniprot No.：
  • 别名：
    Cancer/testis antigen 79; CEP4L; CT79; Predicted testis protein; Testis development protein NYD-SP7; Testis-specific gene 10 protein; Testis-specific protein 10; TSG10_HUMAN; Tsga10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-698
  • 氨基酸序列
    MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI QGNVKVLKSE RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR VETERDVAFT DLRRMTTERD SLRERLKIAQ ETAFNEKAHL EQRIEELECT VHNLDDERME QMSNMTLMKE TISTVEKEMK SLARKAMDTE SELGRQKAEN NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE KIDNFTRQNI AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL AHDNDNLQEQ FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK NILKSEESEN RQMMEQLRKA NEDAENWENK ARQSEADNNT LKLELITAEA EGNRLKEKVD SLNREVEQHL NAERSYKSQI STLHKSVVKM EEELQKVQFE KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE NELDSAHSEI ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR QNYSSNAYHM SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A.
  • 基因功能参考文献：
    1. TSGA10 tends to express variants with shorter 5'UTR. PMID: 28739310
    2. Overexpression of TSGA10 would induce disruption of HIF-1alpha axis and exert potent inhibitory effects on tumor angiogenesis and metastasis. PMID: 26573430
    3. Report role for mir-577/TSGA10 axis in regulation esophageal squamous cell carcinoma progression. PMID: 24294352
    4. TSGA10 should be considered as an autoantigen in a subset of autoimmune polyendocrine syndrome type 1 patients and also in a minority of systemic lupus erythematosus patients PMID: 21198756
    5. TSGA10 could influence the function of antigen presenting cells via its interaction with cytoskeletal proteins such as vimentin PMID: 20797700
    6. over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers PMID: 15107545
    7. The RT-PCR of TSGA10 expression may help in detection of residual clonal cells leading to early diagnosis and better prognostic qualification of the acute lymphoblastic leukemia. PMID: 16406020
    8. TSGA10 is target of immune reactions in Autoimmune polyendocrine syndrome type 1 (APS1). PMID: 18000009

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族：
    CEP135/TSGA10 family
  • 组织特异性：
    Expressed in the testis, in spermatozoa (at protein level). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach.
  • 数据库链接：

    HGNC: 14927

    OMIM: 607166

    KEGG: hsa:80705

    STRING: 9606.ENSP00000347161

    UniGene: Hs.120267