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  4. Recombinant Human Tachykinin-3 (TAC3)

Recombinant Human Tachykinin-3 (TAC3)

  • 中文名称：
    人TAC3重组蛋白
  • 货号：
    CSB-YP887034HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TAC3重组蛋白
  • 货号：
    CSB-EP887034HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TAC3重组蛋白
  • 货号：
    CSB-EP887034HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TAC3重组蛋白
  • 货号：
    CSB-BP887034HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TAC3重组蛋白
  • 货号：
    CSB-MP887034HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TAC3
  • Uniprot No.：
  • 别名：
    Gamma tachykinin 3; Neurokinin B; Neurokinin B like protein; Neurokinin B protein; Neurokinin beta; Neurokinin-B; NeurokininB; Neuromedin K; Neuromedin-K; NeuromedinK; NKB; NKNB ; Preprotachykinin B; PreprotachykininB; PRO 1155; PRO1155 ; TAC 3; TAC3; Tachykinin 3; Tachykinin3; TKNK_HUMAN; ZNEUROK 1; ZNEUROK1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    81-90
  • 氨基酸序列
    DMHDFFVGLM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function.
  • 基因功能参考文献：
    1. Data suggest that basal serum neurokinin B level can be used as an adjunctive parameter to differentiate idiopathic central precocious puberty (ICPP) from premature thelarche (PT). PMID: 28008860
    2. acts through NK3 receptors in granulosa cells to stimulate steroid production PMID: 27580802
    3. mutations in TAC and TACR3 are not a common cause for ICPP. PMID: 24802197
    4. Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. PMID: 25647283
    5. Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities. PMID: 25084101
    6. Amino acid substitution A63P in TAC3 gene was statistically associated with the puberty onset time in Chinese girls. PMID: 25153567
    7. Copper can enter cultured astrocytoma cells and subsequently open plasma membrane calcium channels, but when bound to NKB, copper ion uptake is inhibited. PMID: 23875773
    8. Expression of the gene encoding NKB (TAC3) is up-regulated 20-fold in leiomyomas, compared with matched myometrium. PMID: 23656837
    9. Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype. PMID: 23329188
    10. Interactions between kisspeptins and neurokinin B. PMID: 23550013
    11. Report neurokinin B immunoreactivity in the human brainstem. PMID: 22318412
    12. Sex differences in the neurokinin B system in the human infundibular nucleus. PMID: 23019350
    13. these immunohistochemical data suggest an aging-related moderate enhancement in central NKB signaling. PMID: 23011920
    14. NKB neurons in the arcuate nucleus do not synthesize detectable amounts of kisspeptin and dynorphin in young male humans. These data call for a critical use of the KNDy neuron terminology when referring to the pulse generator of the hypothalamus PMID: 22903610
    15. NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract. PMID: 22424618
    16. The gonadotropin axis dysfunction associated with nCHH due to TAC3/TACR3 mutations is related to a low GnRH pulsatile frequency leading to a low frequency of alpha-subunit pulses and to an elevated FSH/LH ratio. PMID: 22031817
    17. The significantly increased maternal plasma levels of NKB and ET-1 of patients with preeclampsia occur at early pregnancy, before the onset of clinical symptoms. PMID: 19087492
    18. Future studies will be needed to determine whether NKB signaling plays a permissive role in the onset of puberty--REVIEW PMID: 20800582
    19. kisspeptin and neurokinin B are coexpressed in the arcuate nucleus in the mammalian hypothalamus, suggesting that these systems are closely related and potential partners of the regulation of the reproductive axis--REVIEW PMID: 20816945
    20. elevated in plasma of pre-eclamptic women PMID: 20017703
    21. Data describe the distribution and sex dimorphism of kisspeptin-immunoreactive elements in hypothalami, reveal contacts between kisspeptin-immunoreactive fibers and GnRH cells, and colocalize kisspeptins and neurokinin B in the infundibular nucleus. PMID: 20529119
    22. A possible association of a single nucleotide polymorphism in the tachykinin-3 gene and susceptibility to asthma are found. PMID: 20580442
    23. NKB involvement in puberty is reviewed from the perspective of the regulation of puberty. PMID: 20176081
    24. broad cohort of normosmic hypogonadotropic hypogonadism probands was screened for mutations in TAC3/TACR3 to evaluate the prevalence of such mutations and define the genotype/phenotype relationships PMID: 20332248
    25. Possibility of a specific neuroendocrine impairment in patients with alteration of neurokinin B signaling. PMID: 20194706
    26. Physiological significance of neurokinin B in the placenta and during preeclampsia. PMID: 20074343
    27. study demonstrates a paracrine role for neurokinin B in the regulation of fetal placental vascular tone PMID: 12727971
    28. Higher neurokinin B concentrations in normotensive pregnant women may be due to the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. The role of neurokinin B in preeclampsia remains to be determined. PMID: 14634580
    29. NKB plays a role in the maintenance of high placental blood flow in normal pregnancy PMID: 14700748
    30. mode of vascular regulation in which GATA-1 controls NK-B synthesis in erythroid cells PMID: 15123623
    31. three-dimensional structure PMID: 15317475
    32. Results determined the placenta to be the main site of TAC3 expression with levels 2.6-fold higher than the brain and TAC3 expression was found to be significantly higher in pre-eclamptic placenta (1.7-fold, P < 0.05) than in normal controls. PMID: 16709596
    33. Placental mRNA expression of NKB was significantly higher after term and preterm labor (P<0.001) than cesarean section, and highest after preterm labor PMID: 17561251
    34. Altered circulating neurokinin B (NKB) levels in preeclampsia are not due to sequence variants in the encoding genes PMID: 17976896
    35. study confirms previous reports of elevated neurokinin B levels in the plasma of preeclampsia women in the third trimester PMID: 18240076
    36. Neurokinin B is a critical central regulator of human gonadal function. PMID: 19079066
    37. Data show that both the TAC3 endogenous gene and its promoter are regulated, directly or indirectly, by the NRSF transcription factors resulting in both the increased expression of the endogenous gene and increased reporter gene activity. PMID: 19539370
    38. A role for TAC3 neurons in the regulation of steroid negative feedback is suggested by studies of the postmenopausal human hypothalamus. PMID: 18614256

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  • 相关疾病：
    Hypogonadotropic hypogonadism 10 with or without anosmia (HH10)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tachykinin family
  • 数据库链接：

    HGNC: 11521

    OMIM: 162330

    KEGG: hsa:6866

    STRING: 9606.ENSP00000300108

    UniGene: Hs.9730