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  4. Recombinant Human TSC22 domain family protein 3 (TSC22D3)

Recombinant Human TSC22 domain family protein 3 (TSC22D3)

  • 中文名称：
    人TSC22D3重组蛋白
  • 货号：
    CSB-YP860343HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TSC22D3重组蛋白
  • 货号：
    CSB-EP860343HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TSC22D3重组蛋白
  • 货号：
    CSB-EP860343HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TSC22D3重组蛋白
  • 货号：
    CSB-BP860343HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TSC22D3重组蛋白
  • 货号：
    CSB-MP860343HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TSC22D3
  • Uniprot No.：
  • 别名：
    Delta sleep-inducing peptide immunoreactor; DIP; DSIP immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; Dsip1; Dsipi; GILZ; Glucocorticoid-induced leucine zipper protein; hDIP; Protein DIP; T22D3_HUMAN; TSC-22-like protein; TSC-22-related protein; TSC-22R; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC22 related inducible leucine zipper 3; TSC22D3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-134
  • 氨基酸序列
    MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAI DNKIEQAMDL VKNHLMYAVR EEVEILKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SCLSPEEPAP ESPQVPEAPG GSAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
  • 基因功能参考文献：
    1. The mRNA expression of GILZ was significantly correlated with Systemic Lupus Erythematosus Disease Activity Index score. PMID: 28601944
    2. We propose a novel role of GILZ in contributing to corticoid-induced leptin and leptin receptor expression in osteoarthritis synovial fibroblasts PMID: 27716396
    3. TSC22D3 gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure. PMID: 28784648
    4. Overall, these results suggest that GILZ antagonizes the pro-inflammatory effects of TNFa in human adipocytes, and its downregulation in obesity may contribute to adipose inflammation and dysregulated adipokine production, and thereby systemic metabolism. PMID: 27178044
    5. Under endoplasmic reticulum stress conditions, overexpression of GILZ significantly reduced activation of mitochondrial pathway of apoptosis by maintaining Bcl-xl level. GILZ protein affects the unfolded protein response signaling shifting the balance towards pro-survival signals as judged by down-regulation of CHOP, ATF4, XBP1s mRNA and increase in GRP78 protein level. PMID: 27416758
    6. results reveal GILZ to be a new actor in apoptosis regulation in neutrophil-like cells involving JNK and Mcl-1. PMID: 26384220
    7. GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus. PMID: 26612340
    8. our data suggest that GILZ is a key regulator of macrophage functions. PMID: 25964494
    9. L-GILZ stabilizes p53 proteins by decreasing p53 ubiquitination and increasing MDM2 ubiquitination. PMID: 25168242
    10. The N-terminal part of L-GILZ protein is responsible for Ras/L-GILZ protein-to-protein interaction, important for the control of proliferation rate of spermatogonia. PMID: 24993177
    11. PUVA directly stimulates GILZ expression. PMID: 24215840
    12. Data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36. PMID: 24747114
    13. Inhibition of epithelial injury repair by dexamethasone is mediated in part by activation of GILZ. PMID: 23573276
    14. study suggests that GILZ variants are not common causes of SCO and NOA in Australian or American men PMID: 23494955
    15. Exogenous GILZ exerts inhibitory effects on endothelial cell adhesive function via a novel pathway involving modulation of NF-kappaB p65 DNA binding and MAPK activity. PMID: 23729444
    16. Delta-sleep inducing peptide entrapment and release from polymer hydrogels based on modified polyvinyl alcohol in vitro PMID: 23650723
    17. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ. PMID: 23440419
    18. Glucocorticoid-inducible genes GILZ and SGK-1 might be promising candidate markers for hippocampal volume changes relevant for diseases like MDD. PMID: 22832853
    19. The data showed a MyD88- and TTP-dependent GILZ downregulation in human macrophages upon Toll-like receptor activation. Suppression of GILZ is mediated by mRNA destabilization, which might represent a regulatory mechanism in macrophage activation. PMID: 22539300
    20. High GILZ mRNA expression was independently associated with increased risk for a high level of posttraumatic stress disorder symptoms. PMID: 22137507
    21. these results demonstrate that GILZ is a key inhibitor of the mTORC2 pathway. PMID: 21804606
    22. Data show that together with GILZ, chemokine CX3CL1 emerges as a regulator of cell proliferation, which may be of potential clinical relevance for the selection of the most appropriate treatment for EOC patients. PMID: 21750716
    23. UL14 of herpes simplex virus type 1 interacts with cellular factor TSC22D3 during replication. PMID: 21512757
    24. The glucocorticoid-induced leucine zipper protein GILZ is a glucocorticoid-responsive molecule with signal transduction interactions, many of which are operative in inflammatory diseases; it could be a key endogenous regulator of the immune response. PMID: 21556028
    25. Taking into account the unique role of DCs within the allo-HSCT context, novel preventive and curative therapeutics for GVHD might be based on the selective induction of GILZ expression in vivo PMID: 20970683
    26. GILZ1 inhibits SGK1 ubiquitinylation and subsequent proteasome-mediated degradation, thereby prolonging its half-life and increasing its steady-state expression. PMID: 20947508
    27. GILZ expression provokes a Crm-1-dependent nuclear exclusion of FOXO3 leading to its relocalization to the cytoplasm. PMID: 20018851
    28. Implication of the transcription factor GILZ in the pathophysiology of glucocorticoid-induced osteoporosis by regulating osteoblast maturation and bone turnover. PMID: 19875485
    29. GILZ activates AKT, a crucial signaling molecule in tumorigenesis appearing as a potential key molecule in epithelial ovarian cancer. PMID: 19814803
    30. Glucocorticoids and IL-10 stimulated macrophage production of GILZ, which displayed activities related to anti-inflammatory and immunosuppressive effects. PMID: 12393603
    31. GILZ is a transiently expressed protein induced upon IL-2 withdrawal that protects T cells from the onset of apoptosis. PMID: 15031210
    32. Overexpression of the Forkhead transcription factor FoxO3 enhances GC-induced gilz mRNA expression. PMID: 15705665
    33. analysis of a novel link between GILZ and regulation of epithelial sodium transport through modulation of ERK signaling PMID: 16216878
    34. GILZ is critical for commitment of DCs to differentiate into regulatory DCs and to the generation of antigen-specific Tregs. PMID: 17356131
    35. multiple GILZ isoforms are expressed in most cells and tissues and that these play distinct roles in regulating proliferation and ion transport. PMID: 17956870
    36. Lower basal plasma cortisol levels and a lower expression of corticosteroid receptors and GILZ in fibromyalgia patients when compared to healthy controls. PMID: 18468809
    37. GILZ is a mediator of glucocorticoid killing, and is regulated by PI3-kinase/AKT. PMID: 18499442
    38. Down-regulated expression of GILZ may contribute to the pathogenesis of CRSsNP and CRSwNP and associate with response to surgery. GILZ expression in the upper airways can be regulated differentially by different cytokines. PMID: 19260870
    39. GILZ1 and SGK1 provide a physical and functional link between the PI3K- and Raf-1-dependent signaling modules PMID: 19380724

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.
  • 蛋白家族：
    TSC-22/Dip/Bun family
  • 组织特异性：
    Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage.
  • 数据库链接：

    HGNC: 3051

    OMIM: 300506

    KEGG: hsa:1831

    STRING: 9606.ENSP00000314655

    UniGene: Hs.522074