Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human T-cell leukemia virus 2 Protein Tax-2 (tax)

Recombinant Human T-cell leukemia virus 2 Protein Tax-2 (tax)

  • 中文名称：
    Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax),Yeast
  • 货号：
    CSB-YP365933HQL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax),Yeast
  • 货号：
    CSB-EP365933HQL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax),Yeast
  • 货号：
    CSB-EP365933HQL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax),Yeast
  • 货号：
    CSB-BP365933HQL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax),Yeast
  • 货号：
    CSB-MP365933HQL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    tax
  • Uniprot No.：
  • 别名：
    tax; Protein Tax-2; Trans-activating transcriptional regulatory protein of HTLV-2
  • 种属：
    Human T-cell leukemia virus 2 (HTLV-2)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-331
  • 氨基酸序列
    MAHFPGFGQS LLYGYPVYVF GDCVQADWCP VSGGLCSTRL HRHALLATCP EHQLTWDPID GRVVSSPLQY LIPRLPSFPT QRTSRTLKVL TPPTTPVSPK VPPAFFQSMR KHTPYRNGCL EPTLGDQLPS LAFPEPGLRP QNIYTTWGKT VVCLYLYQLS PPMTWPLIPH VIFCHPRQLG AFLTKVPLKR LEELLYKMFL HTGTVIVLPE DDLPTTMFQP VRAPCIQTAW CTGLLPYHSI LTTPGLIWTF NDGSPMISGP YPKAGQPSLV VQSSLLIFEK FETKAFHPSY LLSHQLIQYS SFHNLHLLFD EYTNIPVSIL FNKEEADDNG D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication.
  • 基因功能参考文献：
    1. A Luciferase Functional Quantitative Assay for Measuring NF-kB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins.( PMID: 28357663
    2. the role of Tax2-mediated activation of the nuclear factor kappa B (NF-kappaB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1alpha, MIP-1beta and RANTES. PMID: 24116893
    3. In natural HTLV-1 infection cells expressing HTLV-1 Tax protein were significantly more frequent in clones of low abundance in vivo. PMID: 23555266
    4. The s demonstrate that a nonubiquitinable, non-SUMOylable, and nonacetylable human T cell leukemia virus type 2 tax mutant retains a significant ability to activate transcription from a NF-kappaB-dependent promoter. PMID: 23135727
    5. HTLV-1 Tax1 and HTLV-2 Tax2 have many shared activities, but have a number of significantly distinct activities that appear to play key roles in HTLV-1 specific pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2. [REVIEW] PMID: 20017952
    6. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2 growth of Tax2-transformed CTLL-2 cells. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2. PMID: 17140451
    7. The s demonstrate that Tax-2B is modified by ubiquitination and sumoylation. PMID: 19195675
    8. Virus-specific cytotoxic T cell responses against HTLV-2 Tax protein in HTLV-2 infection are characterized for the first time. PMID: 19657093

    显示更多

    收起更多

  • 亚细胞定位：
    Host cytoplasm. Host nucleus. Note=Tax-2 is mainly found in the cytoplasm.
  • 蛋白家族：
    Deltaretrovirus Tax protein family
  • 数据库链接：

    KEGG: vg:1491946