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  4. Recombinant Human Sushi domain-containing protein 2 (SUSD2), partial

Recombinant Human Sushi domain-containing protein 2 (SUSD2), partial

  • 中文名称：
    人SUSD2重组蛋白
  • 货号：
    CSB-YP866225HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SUSD2重组蛋白
  • 货号：
    CSB-EP866225HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SUSD2重组蛋白
  • 货号：
    CSB-EP866225HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SUSD2重组蛋白
  • 货号：
    CSB-BP866225HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SUSD2重组蛋白
  • 货号：
    CSB-MP866225HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    1200011D11Rik; BK65A6.2; FLJ22778; SUSD2; SUSD2_HUMAN; Sushi domain-containing protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.
  • 基因功能参考文献：
    1. platelet activation and binding to high-grade serous ovarian carcinoma cells was inversely correlated with the presence of SUSD2. This represents one of the first tumor proteins known to provide differential platelet interaction based on protein status. PMID: 30335544
    2. suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer PMID: 28841682
    3. Tumors with high levels of SUSD2 staining contained 2-fold more tumor-associated macrophages, mainly of the M2 pro-angiogenic phenotype PMID: 28475599
    4. Low SUSD2 expression is associated with renal cell carcinoma and lung cancer. PMID: 26815503
    5. No evidence of association between polymorphisms in SUSD2 and sporadic amyotrophic lateral sclerosis in Han Chinese PMID: 25677198
    6. s found significantly fewer CD4 tumor infiltrating lymphocytes in breast tumors expressing Susd2. PMID: 23131994
    7. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1. PMID: 23624525

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus. Also expressed in colon; down-regulated in colon cancer tis
  • 数据库链接：

    HGNC: 30667

    OMIM: 615825

    KEGG: hsa:56241

    STRING: 9606.ENSP00000351075

    UniGene: Hs.131819