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  4. Recombinant Human Sulfotransferase 4A1 (SULT4A1)

Recombinant Human Sulfotransferase 4A1 (SULT4A1)

  • 中文名称：
    人SULT4A1重组蛋白
  • 货号：
    CSB-YP883582HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SULT4A1重组蛋白
  • 货号：
    CSB-EP883582HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SULT4A1重组蛋白
  • 货号：
    CSB-EP883582HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SULT4A1重组蛋白
  • 货号：
    CSB-BP883582HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SULT4A1重组蛋白
  • 货号：
    CSB-MP883582HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SULT4A1
  • Uniprot No.：
  • 别名：
    BR STL 1; Brain sulfotransferase like protein; Brain sulfotransferase-like protein; Brain sulphotransferase like; BRSTL1; DJ388M5.3; hBR STL 1; hBR STL; hBR-STL; hBR-STL-1; MGC40032; Nervous system cytosolic sulfotransferase; Nervous system sulfotransferase; NST; OTTHUMP00000028875; ST4A1; ST4A1_HUMAN; Sulfotransferase 4A1; Sulfotransferase family 4A member 1; Sulfotransferase related protein; SULT4A1; SULTX3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-284
  • 氨基酸序列
    MAESEAETPS TPGEFESKYF EFHGVRLPPF CRGKMEEIAN FPVRPSDVWI VTYPKSGTSL LQEVVYLVSQ GADPDEIGLM NIDEQLPVLE YPQPGLDIIK ELTSPRLIKS HLPYRFLPSD LHNGDSKVIY MARNPKDLVV SYYQFHRSLR TMSYRGTFQE FCRRFMNDKL GYGSWFEHVQ EFWEHRMDSN VLFLKYEDMH RDLVTMVEQL ARFLGVSCDK AQLEALTEHC HQLVDQCCNA EALPVGRGRV GLWKDIFTVS MNEKFDLVYK QKMGKCDLTF DFYL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.
  • 基因功能参考文献：
    1. These results show that SULT4A1 is widely expressed in human tissues, but mostly as a splice variant that produces a rapidly degraded protein. Dimerization protects the protein from degradation. PMID: 24988429
    2. Across three psychiatric disorders (n=2815 patients), we observed no consistent association between SULT4A1-1 status and atypical antipsychotic effect PMID: 25340730
    3. This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects. PMID: 24956247
    4. determination of SULT4A1-1 haplotype status might be useful for identifying patients who show an enhanced response to long-term olanzapine treatment. PMID: 21521020
    5. the first immunohistochemical localization of SULT4A1 in human brain PMID: 14623933
    6. Candidate gene for schizophrenia susceptibility. PMID: 16152568
    7. These results provide the first evidence of how genetic variation in Sult4A1 may be related to clinical symptoms and cognitive function in schizophrenia PMID: 18823757
    8. The lack of polymorphisms in the coding region of the SULT4A1 gene is highly unusual and, along with its high conservation between species, suggests that SULT4A1 may have an important function in vivo. PMID: 19125109
    9. Cytosolic SULT4A1 interacts with PIN1. PMID: 19439498

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 组织特异性：
    Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas. Highly expressed in
  • 数据库链接：

    HGNC: 14903

    OMIM: 608359

    KEGG: hsa:25830

    STRING: 9606.ENSP00000332565

    UniGene: Hs.189810