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  4. Recombinant Human Sulfate anion transporter 1 (SLC26A1), partial

Recombinant Human Sulfate anion transporter 1 (SLC26A1), partial

  • 中文名称：
    人SLC26A1重组蛋白
  • 货号：
    CSB-YP880953HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC26A1重组蛋白
  • 货号：
    CSB-EP880953HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC26A1重组蛋白
  • 货号：
    CSB-EP880953HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC26A1重组蛋白
  • 货号：
    CSB-BP880953HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC26A1重组蛋白
  • 货号：
    CSB-MP880953HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC26A1
  • Uniprot No.：
  • 别名：
    EDM4; S26A1_HUMAN; SAT 1; SAT-1; SAT1; Slc26a1; solute carrier family 26 (anion exchanger); member 1; solute carrier family 26 (sulfate transporter); member 1; Solute carrier family 26 member 1; sulfate anion tranporter AT1; Sulfate anion transporter 1; sulfate transporter; sulfate/anion transporter SAT 1 protein; sulfate/anion transporter SAT1 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
  • 基因功能参考文献：
    1. SLC26A1 L348P was associated with lower whole-body bone mineral density (BMD) and higher serum calcium, consistent with the osteochondrodysplasia exhibited by dogs and sheep with naturally occurring, homozygous, loss-of-function mutations in Slc13a1 PMID: 27412988
    2. Human SLC26A1 resembles SLC26 paralogs in its inhibition. PMID: 27125215
    3. Mutations in SLC26A1 gene is associated with Nephrolithiasis. PMID: 27210743
    4. Screened the SLC26A1 gene in a cohort of 13 individuals with recurrent calcium oxalate urolithiasis, which is the commonest type. DNA sequence analyses showed missense mutations in seven patients. PMID: 24250268
    5. SLC26A1 protein,point mutation is highly responsible for the hearing loss of newborns. PMID: 23815884
    6. The oxalate precursor glyoxylate was identified as a substrate of sat-1. Upregulated expression of sat-1 mRNA and of sat-1 protein indicates that glyoxylate may be responsible for the elevated oxalate release from hepatocytes observed in hyperoxaluria. PMID: 21093948
    7. Characterization of the SAT1 gene and protein function. PMID: 12713736
    8. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
    9. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA. PMID: 17881426

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  • 相关疾病：
    Nephrolithiasis, calcium oxalate (CAON)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族：
    SLC26A/SulP transporter (TC 2.A.53) family
  • 组织特异性：
    Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung.
  • 数据库链接：

    HGNC: 10993

    OMIM: 167030

    KEGG: hsa:10861

    STRING: 9606.ENSP00000354721

    UniGene: Hs.658244