Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Stromelysin-3 (MMP11)

Recombinant Human Stromelysin-3 (MMP11)

  • 中文名称：
    人MMP11重组蛋白
  • 货号：
    CSB-YP014658HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MMP11重组蛋白
  • 货号：
    CSB-EP014658HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MMP11重组蛋白
  • 货号：
    CSB-EP014658HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MMP11重组蛋白
  • 货号：
    CSB-BP014658HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MMP11重组蛋白
  • 货号：
    CSB-MP014658HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MMP11
  • Uniprot No.：
  • 别名：
    Matrix Metalloproteinase 11; Matrix metalloproteinase-11; MMP-11; Mmp11; MMP11_HUMAN; SL 3; SL-3; SL3; ST3; STMY3; Stromelysin 3; Stromelysin III; Stromelysin-3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    98-488
  • 氨基酸序列
    FVL SGGRWEKTDL TYRILRFPWQ LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC AEPANTFL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important role in the progression of epithelial malignancies.
  • 基因功能参考文献：
    1. We believe that genetic variations in the MMP-11 gene may help to predict early-stage Hepatocellular carcinoma and act as reliable biomarkers for Hepatocellular carcinoma progression PMID: 29725257
    2. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used for the first time to investigate the distribution of MMP-11 in human breast cancer tissues in order to show a possible correlation between cancerous and healthy samples, by differential proteomics and using such differences for possible cancer diagnosis and/or prognosis. PMID: 28801789
    3. s evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a. PMID: 28445974
    4. Results revealed that MMP-11 high expression in oral squamous cell carcinoma (OSCC) samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients. PMID: 28427180
    5. A new prognostic model for HR-/HER2+ breast cancer based on the expression of MMP11 and CD2 was developed and the distant metastasis-free survival for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group. PMID: 28409241
    6. HMGA1 and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans. PMID: 29374701
    7. These results demonstrated that miR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC. PMID: 27364572
    8. the data demonstrate that miR125a5p functions as a tumor suppressor gene and serves an important role in inhibiting osteosarcoma cell migration, invasion and EMT by targeting MMP11. PMID: 27081863
    9. MMP-11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in urothelial carcinomas. PMID: 26861489
    10. Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients. PMID: 27002762
    11. Overexpression of MMP-11 was discovered in sera of cancer patients compared with normal control group as well as in multiple tumor tissue specimens, such as gastric cancer, breast cancer, and pancreatic cancer. At present, some evidence supports that MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence [review] PMID: 26892540
    12. Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease PMID: 26956825
    13. combined effects of the MMP-11 gene polymorphisms and environmental carcinogens are related to an increased risk for the development of OSCC and may be a predictive factor for tumor lymph node metastasis in Taiwanese with OSCC PMID: 24838924
    14. results indicated that both CD147 and MMP-11 may be involved in the progression of colorectal cancer, and they are potential prognostic factors and might become new therapeutic targets for CRC patients PMID: 26507719
    15. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies. PMID: 26084486
    16. High Expression of Matrix Metalloproteinase-11 is associated with Cholangiocarcinoma. PMID: 25987024
    17. study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC PMID: 25423087
    18. MMP-14 function might represent one critical regulatory mechanism to control the extent of pericellular MMP-11 bioavailability and protect cells from excessive/inappropriate MMP-11 function. PMID: 25081520
    19. These findings further suggest MMP11 as a promising biomarker for breast and prostate cabcer. PMID: 24564996
    20. MMP-11 expression was significantly related to clinicopathological parameters, which may be essential to the prediction of disease outcome in patients with invasive ductal carcinoma of the breast. PMID: 23115007
    21. Knockdown of MMP11 expression could inhibit the proliferation and invasion of gastric adenocarcinoma cells probably through down-regulation of the IGF-1 signaling pathway. PMID: 23755751
    22. Findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression. PMID: 23211491
    23. Data suggest that intra- and extracellular tracking of MMP-11-overexpressing cancer cells might contribute to the understanding of the activation pathways leading to MMP-11-mediated invasive processes. PMID: 22927434
    24. MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF-A. PMID: 22768249
    25. expression by fibroblasts associated with poor prognosis in colorectal cancer PMID: 22488635
    26. Results describe MMP-11 expression in human epithelial colon adenocarcinoma cell lines (Caco-2, HT-29 and BCS-TC2). PMID: 22227581
    27. Report MMP11/12 expression in cervical scrapes cells from cervical precursor lesions. PMID: 22076168
    28. MMP11 (metalloproteinase 11) gene shows increased expression in papillary thyroid cancer. PMID: 17091452
    29. MMP-11 is overexpressed in many lobular carcinoma cells, and it may play role in lobular carcinogenesis through increasing resistance to anoikis. PMID: 21773755
    30. Serum levels in Chinese patients with advanced gastric carcinoma are not associated with the response to chemotherapy, but play role in lymph node metastasis and prognosis PMID: 21513571
    31. The MMP-11 is up-regulated by Gli1 and mediates the migration and invasion induced by Gli1 in MDA-MB-231. PMID: 21442356
    32. The expression of stromelysin-3 was closely associated with the invasion and metastasis of laryngeal carcinoma. PMID: 18476627
    33. matrix metalloproteinase 11 is a novel factor in the development and progression of gastric cancer and suggest that matrix metalloproteinase 11 is a marker for advanced gastric cancer. PMID: 20060156
    34. the results of this study indicate that MMP11 polymorphism may be associated with Kawasaki disease in the Korean population PMID: 20230842
    35. High expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence in prostate cancer PMID: 20160732
    36. MMP-11 and CK-20 are probable prognostic markers whose expression reflects the stages of tumor differentiation and LNM of breast cancer. PMID: 19914229
    37. may play role in meningioma invasiveness PMID: 11857311
    38. alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase PMID: 12006591
    39. Data confirmed stromelysin-3's contribution to breast cancer progression and its expression was shown to have a direct negative effect on patients' survival. PMID: 12429794
    40. MMP11 may have a role in the pathogenesis of papillary thyroid carcinoma PMID: 12538453
    41. Active stromelysin-3 increases breast cancer cell survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase PMID: 12845673
    42. ST3 protein was more involved in the pathway of colorectal cancer development in females, distal locations, infiltrative growth patterns and microsatellite stability. PMID: 15459498
    43. central role of PKC isoforms and the negative regulatory function of c-Src in the control of ST3 expression PMID: 15509588
    44. colony formation of MMP11 deficient cells was dramatically inhibited in soft agar and tumorigenicity was reduced in nude mice, respectively PMID: 15582574
    45. cathepsin F, matrix metalloproteinases 11 and 12 are upregulated in cervical cancer PMID: 15989693
    46. MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli PMID: 17085465
    47. proposes that ST-3 induction in tumour fibroblasts leads to the stimulation of the IGF-1R pathway in carcinoma cells, thus enhancing their proliferative capacity PMID: 17233884
    48. MMP11 may play an important role in carcinogenesis and has potential implication as a biomarker for the diagnosis and prognosis of human cancers including gastric cancer. PMID: 18172255
    49. MMP11 exhibits collagenolytic function against collagen VI under malignant conditions. PMID: 18622425
    50. MMP-11 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls. PMID: 19159011

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Specifically expressed in stromal cells of breast carcinomas.
  • 数据库链接：

    HGNC: 7157

    OMIM: 185261

    KEGG: hsa:4320

    STRING: 9606.ENSP00000215743

    UniGene: Hs.143751