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  4. Recombinant Human Sister chromatid cohesion protein DCC1 (DSCC1)

Recombinant Human Sister chromatid cohesion protein DCC1 (DSCC1)

  • 中文名称：
    人DSCC1重组蛋白
  • 货号：
    CSB-YP887133HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DSCC1重组蛋白
  • 货号：
    CSB-EP887133HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DSCC1重组蛋白
  • 货号：
    CSB-EP887133HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DSCC1重组蛋白
  • 货号：
    CSB-BP887133HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DSCC1重组蛋白
  • 货号：
    CSB-MP887133HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DSCC1
  • Uniprot No.：
  • 别名：
    DCC1 ; DCC1_HUMAN; Defective in sister chromatid cohesion 1 homolog; Defective in sister chromatid cohesion protein 1 homolog; DSCC1; hDCC1 ; MGC5528; Sister chromatid cohesion protein DCC1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-393
  • 氨基酸序列
    MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP TLCQQLEDGH SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT PDQLKKEDSH CNIIHTEIFG FSNNYWELRR RRPKLKKLKK LLMENPYEGP DSQKEKDSNS SKYTTEDLLD QIQASEEEIM TQLQVLNACK IGGYWRILEF DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE MIEHCLKCYG KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE EDIAPYIQDL CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.
  • 基因功能参考文献：
    1. E2F-dependent expression of DSCC1 confers anti-apoptotic properties in colorectal cancer cells. PMID: 24465681
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DCC1 family
  • 数据库链接：

    HGNC: 24453

    OMIM: 613203

    KEGG: hsa:79075

    STRING: 9606.ENSP00000322180

    UniGene: Hs.315167