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  4. Recombinant Human Serine/threonine-protein kinase 17A (STK17A)

Recombinant Human Serine/threonine-protein kinase 17A (STK17A)

  • 中文名称：
    人STK17A重组蛋白
  • 货号：
    CSB-YP887013HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人STK17A重组蛋白
  • 货号：
    CSB-EP887013HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人STK17A重组蛋白
  • 货号：
    CSB-EP887013HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人STK17A重组蛋白
  • 货号：
    CSB-BP887013HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人STK17A重组蛋白
  • 货号：
    CSB-MP887013HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STK17A
  • Uniprot No.：
  • 别名：
    DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; DRAK1; EC 2.7.11.1; Serine / threonine kinase 17a death associated protein kinase related 1; Serine/threonine kinase 17a; Serine/threonine protein kinase 17a; Serine/threonine-protein kinase 17A; ST17A_HUMAN; STK17 A; STK17A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-414
  • 氨基酸序列
    MIPLEKPGSG GSSPGATSGS GRAGRGLSGP CRPPPPPQAR GLLTEIRAVV RTEPFQDGYS LCPGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTR DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP EINSDTDKSE TKESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF EEPLLQEIPG EFIY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
  • 基因功能参考文献：
    1. These findings suggest that DRAK1 translocates in response to stimuli and induces apoptosis through its interaction with specific binding partners, p53 and/or ANT2. PMID: 29397938
    2. the present study was the first to find localization of STK17A in normal bile canaliculi. PMID: 26305096
    3. DRAK1 was predominantly localized in the cytoplasm and bound to Smad3, thereby interrupting Smad3/Smad4 complex formation, which is the core process for the induction of tumor suppressor genes by TGF-beta1 PMID: 25531329
    4. STK17A provides a proliferative and survival advantage to GBM cells PMID: 24312360
    5. When analyzing STK17A haplotypes distribution, we found association between TGGTC, TAGTC and AAGAT haplotypes and risk to develop SLE PMID: 23860322
    6. identified STK17A as a novel direct target of p53 and a modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. PMID: 21489989

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
  • 组织特异性：
    Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 11395

    OMIM: 604726

    KEGG: hsa:9263

    STRING: 9606.ENSP00000319192

    UniGene: Hs.709489