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  4. Recombinant Human Serine protease inhibitor Kazal-type 7 (SPINK7)

Recombinant Human Serine protease inhibitor Kazal-type 7 (SPINK7)

  • 中文名称：
    人SPINK7重组蛋白
  • 货号：
    CSB-YP022580HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SPINK7重组蛋白
  • 货号：
    CSB-EP022580HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SPINK7重组蛋白
  • 货号：
    CSB-EP022580HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SPINK7重组蛋白
  • 货号：
    CSB-BP022580HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SPINK7重组蛋白
  • 货号：
    CSB-MP022580HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SPINK7
  • Uniprot No.：
  • 别名：
    SPINK7; ECG2; UNQ745/PRO1474; Serine protease inhibitor Kazal-type 7; Esophagus cancer-related gene 2 protein; ECRG-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-85
  • 氨基酸序列
    S EAASLSPKKV DCSIYKKYPV VAIPCPITYL PVCGSDYITY GNECHLCTES LKSNGRVQFL HDGSC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable serine protease inhibitor.
  • 基因功能参考文献：
    1. n cultured keratinocytes, SPINK7 mRNA expression was up-regulated by IL-17A together with IFNgamma PMID: 28852849
    2. Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2 PMID: 26434587
    3. ECRG2 in combination with cisplatin (DDP) can inhibit viability and induce apoptosis in esophageal cancer DDP-resistant cells, possibly via upregulation of p53 expression and downregulation of PCNA expression. PMID: 28348485
    4. miR-1322 can regulate ECRG2 in an allele-specific manner and that serum levels of miR-1322 can serve as a potential diagnostic biomarker for patients with ESCC. PMID: 22315007
    5. Conformational study of ECRG2 using NMR. PMID: 22528291
    6. ECRG2 is a novel member of the Kazal-type serine protease inhibitor family and may function as a tumor suppressor gene regulating the protease cascades during carcinogenesis and invasion of esophageal cancer. PMID: 21042721
    7. ECRG2 regulates invasion/migration partly through ECM degradation and uPA/uPAR/FPRL1 pathway PMID: 19796867
    8. Data suggest that the physical interaction of esophageal cancer related gene 2 (ECRG2) and metallothionein 2A (MT2A) may play an important role in the carcinogenesis of esophageal cancer. PMID: 12646258
    9. Potential interaction partner for ECRG2 might be involved in regulation of cell proliferation and apoptosis and in various physiological processes. PMID: 12970870
    10. Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer PMID: 14639608
    11. Short tandem repeat polymorphism TCA3/TCA3 in exon 4 of ECRG2 is associated with poor relapse-free survival in surgically completely resected oral squamous cell carcinoma patients and might be a potential prognostic marker PMID: 17418617
    12. results suggest that ECRG2 inhibits aggressiveness of cancer cell, possibly through the down-regulation of uPA/plasmin activity PMID: 17602171
    13. genetically fixed short tandem repeat polymorphism TCA3/TCA3 in exon 4 of ECRG2 is associated with poor clinical outcome in surgically treated esophageal cancer patients and might be a potential prognostic marker PMID: 17693286
    14. ECRG2 is important for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in human cancers. PMID: 18162463
    15. the ECRG2 TCA (3)/TCA (4) genotype is associated with the risk of oesophageal carcinoma in a North Indian population. PMID: 18618216
    16. uPA-binding loops of ECRG2 are in correspondence with the reactive site loops for binding of serine proteinase in turkey ovomucoid third domain (OMTKY3). PMID: 18824154
    17. ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway. PMID: 19717562

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 24643

    KEGG: hsa:84651

    STRING: 9606.ENSP00000274565

    UniGene: Hs.244569