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  4. Recombinant Human Selenoprotein H (SELH)

Recombinant Human Selenoprotein H (SELH)

  • 中文名称：
    人SELENOH重组蛋白
  • 货号：
    CSB-YP815593HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SELENOH重组蛋白
  • 货号：
    CSB-EP815593HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SELENOH重组蛋白
  • 货号：
    CSB-EP815593HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SELENOH重组蛋白
  • 货号：
    CSB-BP815593HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SELENOH重组蛋白
  • 货号：
    CSB-MP815593HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SELENOH
  • Uniprot No.：
  • 别名：
    C11orf31; Chromosome 11 open reading frame 31; Selenoprotein H; SelH; SELH_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-122
  • 氨基酸序列
    MAPRGRKRKA EAAVVAVAEK REKLANGGEG MEEATVVIEH CTSURVYGRN AAALSQALRL EAPELPVKVN PTKPRRGSFE VTLLRPDGSS AELWTGIKKG PPRKLKFPEP QEVVEELKKY LS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in a redox-related process.
  • 基因功能参考文献：
    1. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development PMID: 27588899
    2. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. PMID: 25336634
    3. We conclude that the effects of selenoprotein H on mitochondrial biogenesis and mitochondrial function are probably mediated through protein kinase A-CREB-PGC-1alpha and Akt/protein kinase B-CREB-PGC-1alpha pathways. PMID: 23220172
    4. Overexpression of SelH promotes mitochondrial biogenesis and improves mitochondrial functional performance. PMID: 20656065
    5. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21048031
    6. SelH is a novel nucleolar oxidoreductase that may have functions which are regulated by redox and dependent on the trace element selenium PMID: 17337453
    7. hSelH overexpression protects cells from UVB irradiation-induced murine hippocampal neuronal cell death by reducing the superoxide formation. PMID: 17389926
    8. selenoprotein H is a redox-responsive DNA-binding protein of the AT-hook family and functions in regulating expression levels of genes involved in de novo glutathione synthesis and phase II detoxification in response to redox status. PMID: 17526492
    9. t SelH protects neurons against UVB-induced damage by inhibiting apoptotic cell death pathways PMID: 19766117

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  • 蛋白家族：
    SelWTH family
  • 数据库链接：

    HGNC: 18251

    OMIM: 607914

    KEGG: hsa:280636

    STRING: 9606.ENSP00000373509

    UniGene: Hs.655373